# US 12,213,960 B2 · Method of preventing or improving UV-induced skin damage using hydroangenol as active ingredient

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- Number: US 12,213,960 B2
- Document ID: US12213960B2
- Status: Granted
- Kind: B2
- Application number: 17/196,513
- Filed: 2021-03-09
- Published: 2021-07-01
- Granted: 2025-02-04
- Earliest claimed: 2017-12-19
- Assignees: Cosmaxbio Co., Ltd.
- Applicants: Cosmaxbio Co., Ltd.
- Inventors: Sun Hee Lee; Keun Suk Lee; Hyoun Jea Kim; Yu Kyong Shin; Hye Shin Ahn; Kyung Tae Lee; Ji Sun Shin
- Web page: https://patentgrep.com/patent/US12213960B2

## CPC

- A61K 31/366: having six-membered rings, e.g. delta-lactones
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A61K 8/498: {having 6-membered rings or their condensed derivatives, e.g. coumarin}
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 9/0058: {Chewing gums (non-medicinal aspects, preparing chewing gum A23G4/00; chewing gum for care of the teeth or oral cavity, e.g. with breath freshener A61Q11/00)}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 36/185: Magnoliopsida (dicotyledons)
- A61K 47/44: Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin (synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14)
- A61Q 19/004: {Aftersun preparations}
- A61Q 19/08: Anti-ageing preparations
- A61K 2236/333: using mixed solvents, e.g. 70% EtOH
- A61K 2236/39: Complex extraction schemes, e.g. fractionation or repeated extraction steps
- A61K 2236/53: Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
- A61K 2800/92: Oral administration
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Provided is a method for preventing or improving UV-induced skin damage of a subject in need thereof, which comprises administering to the subject an effective amount of a composition containing hydrangenol derived from the extract of Hydrangea serrata as an active ingredient. The composition containing hydrangenol derived from the extract of Hydrangea serrata is able to increase secretion of hyaluronic acid and procollagen type-1 and inhibit secretion of MMP-1 in skin cells, and therefore effective in preventing or improving UV-induced damage of skin cells. Accordingly, the hydrangenol-containing composition is usefully available as a quasi-drug, drug, food, or cosmetic composition.

## Claims

### Claim 1

A method for preventing or improving UV-induced skin damage of a subject in need thereof, the method comprising: administering to the subject an effective amount of a composition containing hydrangenol represented by the following chemical formula 1 as an active ingredient:
wherein the hydrangenol prevents or improves UV-induced skin damage of the subject by accelerating proliferation of skin cells damaged by UV radiation, reducing production of MMP-1, and increasing production of procollagen and hyaluronic acid.

### Claim 2 (depends on 1)

The method as claimed in claim 1, wherein the hydrangenol is isolated from an extract of leaf of Hydrangea serrata.

### Claim 3 (depends on 2)

The method as claimed in claim 2, wherein the hydrangenol is obtained by ethanol extraction of leaf of Hydrangea serrata, ethanol or methanol solvent fractionation, and recrystallization.

### Claim 4 (depends on 1)

The method as claimed in claim 1, wherein the hydrangenol is contained in an amount of 0.0001 to 10 wt. % with respect to the total weight of the composition.

### Claim 5 (depends on 1)

The method as claimed in claim 1, wherein the composition is used to moisturize the skin irritated by UV radiation or improve wrinkles.

### Claim 6 (depends on 1)

The method as claimed in claim 1, wherein the composition is for oral administration and has at least one dosage form selected from the group consisting of tablet, granule, pill, capsule, liquid, chewable gel, and gum.

### Claim 7 (depends on 1)

The method as claimed in claim 1, wherein the composition is for topical administration on the skin and has at least one dosage form selected from the group consisting of toner, essence, nutrition cream, moisturizing cream, gel, lotion, and ointment.

### Claim 8 (depends on 1)

The method as claimed in claim 1, wherein the composition is a quasi-drug, drug, food, or cosmetic composition.