# US 12,213,838 B2 · Temporally balanced multi-mode master imaging sequence for ultrasonic contrast imaging > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,213,838 B2 - Document ID: US12213838B2 - Status: Granted - Kind: B2 - Application number: 17/617,360 - Filed: 2020-06-04 - Published: 2022-07-14 - Granted: 2025-02-04 - Earliest claimed: 2019-06-11 - Assignees: Koninklijke Philips N.V. - Applicants: Koninklijke Philips N.V. - Inventors: Thanasis Loupas; Paul Sheeran; Charles Tremblay-Darveau; Jeffry Earl Powers - Web page: https://patentgrep.com/patent/US12213838B2 ## CPC - A61B 8/5276: {due to motion} - A61B 8/06: Measuring blood flow - A61B 8/085: {for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules} - A61B 8/14: Echotomography - A61B 8/463: {characterised by displaying multiple images or images and diagnostic data on one display} - A61B 8/481: {involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream} - A61B 8/5207: {involving processing of raw data to produce diagnostic data, e.g. for generating an image} - G01S 7/5202: {for pulse systems} - G01S 7/52026: {Extracting wanted echo signals (Doppler systems G01S15/50; Doppler short range imaging systems G01S15/8979)} - G01S 7/52039: {exploiting the non-linear response of a contrast enhancer, e.g. a contrast agent (diagnostic techniques involving the use of contrast agents A61B8/481)} - G01S 15/8915: {using a transducer array} - A61B 8/0891: {for diagnosis of blood vessels} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G01S: RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES ## Abstract A particular sequence of ultrasound transmissions and corresponding echo receptions enables the production of Amplitude Modulated (AM) and Amplitude Modulated Phase Inverted (AMPI) signals that are temporally balanced. Temporal balancing significantly reduces tissue artifacts caused by movement of tissue during acquisition of the ultrasound echoes. Additionally, in combining the selected echo signals to produce the AM5 and AMPI signals, and optionally a Phase Inverted (PI) signal, each of the echo signals is equally weighted to facilitate an amplitude balance that avoids different echoes affecting the produced AM, AMPI, and PI signals differently. ## Claims ### Claim 1 An ultrasound method for distinguishing non-perfused tissue from at least one of blood flow or blood perfusion comprising: transmitting a sequence of ultrasound signals including a first complement and a second complement to a patient via a plurality of ultrasound transducer elements; receiving a sequence of echo signals corresponding to the sequence of ultrasound signals; combining a first selected set of echo signals to produce an Amplitude Modulated (AM) signal; combining a second selected set of echo signals to produce an Amplitude Modulated Phase Inversion (AMPI) signal; creating at least one image based on at least one of the AM signal or the AMPI signal; displaying the at least one image; wherein at least one of an order of at least one of the first selected set of echo signals or the second selected set of echo signals is temporally balanced by having echo signals of the first complement in the first selected set or the second selected set occur on each side of an echo signal of the second complement in the first selected set or the second selected set, or center times of the first selected set of echo signals or the second selected set of echo signals are temporally balanced by having center times of echo signals of the first complement in the first selected set or the second selected set evenly displaced around a center time of an echo signal of the second complement in the first selected set or the second selected set; wherein a characteristic of each of the echo signals is set to be equal in each combining to produce the AM and AMPI signals. ### Claim 2 (depends on 1) The method of claim 1, wherein the sequence of ultrasound signals comprises a sequence of a first signal, a second signal, a third signal, a fourth signal, and a fifth signal; wherein the first signal and the fifth signal correspond to a transmission through a first half of the plurality of ultrasound transducer elements at a first phase; wherein the second signal corresponds to a transmission through the plurality of transducer elements at the first phase; wherein the third signal corresponds to a transmission through a second half of the plurality of ultrasound transducer elements at the first phase; and wherein the fourth signal corresponds to a transmission through the plurality of transducer elements at a second phase. ### Claim 3 (depends on 2) The method of claim 2, wherein the first signal corresponds to a first echo signal, wherein the second signal corresponds to a second echo signal, wherein the third signal corresponds to a third echo signal. ### Claim 4 (depends on 2) The method of claim 2, wherein the AMPI signal comprises a sum of the third signal, the fourth signal, and the fifth signal. ### Claim 5 (depends on 2) The method of claim 2, wherein the method comprises summing the second signal and the fourth signal to provide a Phase Inverted (PI) signal, and wherein the at least one image is also based on the PI signal. ### Claim 6 (depends on 1) The method of claim 1, wherein the AMPI signal produced by combining the second selected set of echo signals is temporally balanced. ### Claim 7 (depends on 1) The method of claim 1, wherein the at least one image is further based on a spectral response of at least one of the AM signal or the AMPI signal. ### Claim 8 (depends on 1) The method of claim 1, wherein the at least one image is further based on a signal-to-noise ratio of at least one of the AM signal or the AMPI signal. ### Claim 9 (depends on 1) The method of claim 1, wherein the at least one image comprises at least two images, and wherein the method comprises simultaneously displaying the at least two images. ### Claim 10 (depends on 1) The method of claim 1, wherein the at least one image comprises a combination image that is based on both the AM and AMPI signals. ### Claim 11 (depends on 1) The method of claim 1, wherein each of the selected first set of echo signals and the selected second set of echo signals comprises a first set of echo signals and a second set of echo signals; wherein a form of the first set of echo signals and the second set of echo signals are complementary; wherein the first set of echo signals has a first center time; wherein the second set of echo signals has a second center time; and wherein the first center time is equal to the second center time. ### Claim 12 (depends on 1) The method of claim 1, further comprising injecting contrast-enhancing microbubbles in a vessel of the patient; wherein the at least one image displays a flow of the microbubbles through the patient. ### Claim 13 (depends on 1) An ultrasound system, comprising: a plurality of transducer elements configured to transmit a sequence of ultrasound pulses and to receive a sequence of echo signals in response to the sequence of ultrasound pulses; and a processing circuit configured to generate the sequence of ultrasound pulses and to process the sequence of echo signals as claimed in claim 1. ### Claim 14 A non-transitory computer-readable medium that includes a program that, when executed by a processing system, causes the processing system to: transmit a sequence of ultrasound signals including a first complement and a second complement to a patient via a plurality of ultrasound transducer elements; receive a sequence of echo signals corresponding to the sequence of ultrasound signals; combine a first selected set of echo signals to produce an Amplitude Modulated (AM) signal; combine a second selected set of echo signals to produce an Amplitude Modulated Phase Inversion (AMPI) signal; create at least one image based on at least one of the AM signal or the AMPI signal; display the at least one image; wherein at least one of an order of each of the first selected set of echo signals and the second selected set of echo signals is temporally balanced by having echo signals of the first complement in the first selected set or the second selected set occur on each side of an echo signal of the second complement in the first selected set or the second selected set, or center times of the first selected set of echo signals and the second selected set of echo signals are temporally balanced by having center times of echo signals of the first complement in the first selected set or the second selected set evenly displaced around a center time of an echo signal of the second complement in the first selected set or the second selected set; wherein a characteristic of each of the echo signals is set to be equal in each combining to produce the AM and AMPI signals; and wherein the at least one image minimizes an appearance of motion-induced tissue artifacts in the images. ### Claim 15 (depends on 14) The medium of claim 14, wherein: the sequence of ultrasound signals comprises a sequence of a first signal, a second signal, a third signal, a fourth signal, and a fifth signal; the first signal and the fifth signal correspond to a transmission through a first half of the plurality of ultrasound transducer elements at a first phase; the second signal corresponds to a transmission through the plurality of transducer elements at the first phase; the third signal corresponds to a transmission through a second half of the plurality of ultrasound transducer elements at the first phase; and the fourth signal corresponds to a transmission through the plurality of transducer elements at a second phase.