# US 12,213,721 B2 · System, method and computer-accessible medium for catheter-based optical determination of met-myoglobin content for estimating radiofrequency ablated, chronic lesion formation in tissue > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,213,721 B2 - Document ID: US12213721B2 - Status: Granted - Kind: B2 - Application number: 16/864,415 - Filed: 2020-05-01 - Published: 2020-10-22 - Granted: 2025-02-04 - Earliest claimed: 2015-09-11 - Assignees: The Trustees of Columbia University in the City of New York - Applicants: The Trustees of Columbia University In the City of New York - Inventors: Christine Hendon; Rajinder Singh-Moon; Soo Young Park - Web page: https://patentgrep.com/patent/US12213721B2 ## CPC - A61B 18/12: by passing a current through the tissue to be heated, e.g. high-frequency current - A61B 18/1206: {Generators therefor} - A61B 5/0075: {by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy (A61B5/0071 takes precedence)} - G16H 20/40: relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture - A61B 5/0084: {for introduction into the body, e.g. by catheters (A61B5/1459 takes precedence)} - A61B 5/14546: {for measuring analytes not otherwise provided for, e.g. ions, cytochromes} - A61B 5/14552: {Details of sensors specially adapted therefor} - A61B 5/4848: {Monitoring or testing the effects of treatment, e.g. of medication} - A61B 5/6852: {Catheters} - A61B 5/7264: {Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems} - A61B 18/1492: {having a flexible, catheter-like structure, e.g. for heart ablation (A61B18/1477 takes precedence)} - A61B 2017/00061: {spectrum} - A61B 2018/00351: {Heart} - A61B 2018/00577: {Ablation} - A61B 2018/00642: {with feedback, i.e. closed loop control} - A61B 2018/00702: {Power or energy} - A61B 2018/00839: {Bioelectrical parameters, e.g. ECG, EEG} - A61B 2090/061: {for measuring dimensions, e.g. length} - A61B 2090/306: {using optical fibres} - A61B 2218/002: Irrigation - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract Exemplary system, method and computer-accessible medium for determining a characteristic(s) of a tissue(s), can be provided which can include, for example, ablating the tissue(s), illuminating the tissue(s) during the ablation procedure; and continuously determining the characteristic(s) based on the ablation and illumination procedures. The tissue(s) can be ablated using radiofrequency ablation. The illumination procedure can be performed with a radiation in a visible spectrum. ## Claims ### Claim 1 A method for determining at least one characteristic of at least one tissue, comprising: ablating the at least one tissue; illuminating, by a source, the at least one tissue during the ablation procedure; receiving, by a detector, diffuse reflectance spectra in a wavelength range of 600 nm-1000 nm based on the illumination procedure; and using a computer hardware arrangement, continuously determining the at least one characteristic based on the ablation and illumination procedures and the received diffuse reflectance spectra, wherein a separation distance between the source and the detector is between 0.8 mm and 1.7 mm. ### Claim 2 (depends on 1) The method of claim 1, further comprising ablating the at least one tissue using radiofrequency ablation. ### Claim 3 (depends on 1) The method of claim 1, wherein the illumination procedure is performed with a radiation in a visible spectrum. ### Claim 4 (depends on 1) The method of claim 1, further comprising inverting the diffuse reflectance spectra using an inverse Monte Carlo procedure. ### Claim 5 (depends on 4) The method of claim 4, further comprising determining a concentration of at least one of (i) an oxy-myoglobin, (ii) a deoxy-myoglobin or (iii) a met-myoglobin based on the inverted diffuse reflectance spectra. ### Claim 6 (depends on 4) The method of claim 4, further comprising: determining a concentration of a met-myoglobin based on the inverted diffuse reflectance spectra; and performing at least one of (i) an analysis of variance test or (ii) a Tukey's multiple comparison test on the met-myoglobin concentration. ### Claim 7 (depends on 4) The method of claim 4, further comprising fitting the inverted diffuse reflectance spectra to a wavelength dependent model. ### Claim 8 (depends on 7) The method of claim 7, further comprising receiving a plurality of coefficients based on results of the fitting step, wherein the at least one characteristic is determined based on the coefficients. ### Claim 9 (depends on 1) The method of claim 1, wherein the at least one characteristic includes a classification of the tissue. ### Claim 10 (depends on 9) The method of claim 9, wherein the classification is regarding the at least one tissue having a lesion thereon. ### Claim 11 (depends on 1) The method of claim 1, further comprising at least one of (i) repeating the ablation and illumination procedures until a permanent lesion is formed on the at least one tissue, (ii) determining a baseline diffuse reflectance spectra associated with the at least one tissue before the ablation procedure, (iii) flushing the at least one tissue, or (iv) electrically mapping a surface of the at least on tissue. ### Claim 12 (depends on 1) The method of claim 1, wherein the at least one tissue is illuminated and the diffuse reflectance spectra is received using a single fiber. ### Claim 13 (depends on 1) The method of claim 1, further comprising continuously and simultaneously detecting the ablating the at least one tissue and a return light radiation based on the illuminating of the at least one tissue. ### Claim 14 A system for determining at least one characteristic of at least one tissue, comprising a first electromagnetic radiation source configured to (i) generate at least one first radiation and (ii) provide the at least one first radiation to the at least one tissue so as to partially ablate the at least one tissue; a second electromagnetic radiation source configured to (i) generate at least one second radiation, and (ii) provide the at least one second radiation to the at least one tissue; a detector arrangement configured to (i) continuously obtain a return radiation from the at least one tissue that is based on the at least one second radiation impacting the at least one tissue and the at least partial ablation caused by the at least one first radiation, (ii) receive diffuse reflectance spectra in a wavelength range of 600 nm-1000 nm based on the illumination procedure, and (iii) provide data associated with at least one further characteristic of the returned radiation; and a computer processing arrangement configured to continuously determine the at least one characteristic based on the data and the received diffuse reflectance spectra, wherein a separation distance between the second electromagnetic radiation source and the detector arrangement is between 0.8 mm and 1.7 mm. ### Claim 15 (depends on 14) The system of claim 14, wherein the data includes information as to whether the at least one tissue has been permanently damaged. ### Claim 16 (depends on 14) The system of claim 14, wherein at least one of (i) the at least one second radiation is in a visible spectrum, (ii) the at least one characteristic includes a classification of the tissue, or (iii) the classification is regarding the at least one tissue having a lesion thereon. ### Claim 17 (depends on 14) The system of claim 14, further comprising at least one of (i) at least one flushing arrangement configured to flush the at least one tissue, or (ii) a voltage arrangement configured to generate at least one voltage, wherein the detector arrangement is further configured to obtain a return voltage from the at least one tissue that is based on the at least one second radiation impacting the at least one tissue. ### Claim 18 (depends on 14) The system of claim 14, wherein at least one of the at least one first radiation or the at least one second radiation is provided in a single fiber, and wherein the detector receives the return radiation from the single fiber.