# US 12,213,698 B2 · Systems, methods and devices for removal of thrombus and/or soft plaque with asymmetric mass distribution within working region of impeller

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- Number: US 12,213,698 B2
- Document ID: US12213698B2
- Status: Granted
- Kind: B2
- Application number: 18/070,753
- Filed: 2022-11-29
- Published: 2023-03-23
- Granted: 2025-02-04
- Earliest claimed: 2020-09-03
- Assignees: Cardiovascular Systems, Inc.
- Applicants: Cardiovascular Systems, Inc.
- Inventors: Joseph P. Higgins; Nicholas W. Rydberg; Matthew D. Cambronne; Jeffrey R. Stone
- Web page: https://patentgrep.com/patent/US12213698B2

## CPC

- A61B 17/320758: {with a rotating cutting instrument, e.g. motor driven (A61B17/320725, A61B17/32075 and A61B17/320783 take precedence; for removing intra-ocular material A61F9/00763; endoscopic rotatable cutting instruments A61B17/32002)}
- A61B 2017/22038: {with a guide wire}
- A61B 2017/320766: {eccentric}
- A61B 2017/320775: {Morcellators, impeller or propeller like means}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A thrombectomy system is provided that, in various embodiments, a rotating impeller that may be translated within limits along a guidewire and within a catheter. The rotating impeller is, during operation, either located entirely inside or outside of the distal end of the catheter's lumen or at least partially outside of the distal end of the catheter's lumen. In some cases, the impeller may be prevented from rotating if at least partially inside the catheter's lumen. The rotating impeller may achieve a working diameter that is greater than its resting diameter.

## Claims

### Claim 1

A thrombus disruption and removal system, comprising:
a drive shaft defining a proximal end and a distal end and an axis of rotation;
a working region defined near, or at, the distal end of the drive shaft, the working region comprising:
an impeller hub defining a wall and attached to and/or surrounding the drive shaft;
a plurality of impeller blades attached to, or integrated with, the impeller hub and extending radially therefrom, at least one impeller blade being helical;
at least a portion of the drive shaft engaging the impeller hub and extending at least partially through a lumen defined through the impeller hub;
a prime mover coupled to the proximal end of the drive shaft and, together with the drive shaft, configured to rotate the impeller hub and to translate the working region,
wherein at least one of the impeller blades comprises a surface area that is greater than the surface area of any one of the remaining impeller blades in the plurality of impeller blades.

### Claim 2 (depends on 1)

The thrombus disruption and removal system of claim 1, wherein a working diameter of the impeller blades achieved during rotation of the impeller is greater than a resting diameter of the impeller blades.

### Claim 3 (depends on 1)

The thrombus disruption and removal system of claim 1, wherein the at least one of the impeller blades comprises a mass that is greater than the mass of any one of the remaining impeller blades in the plurality of impeller blades.

### Claim 4 (depends on 1)

The thrombus disruption and removal system of claim 1, wherein at least one of the impeller blades comprising a mass that is greater than the mass of any one of the remaining impeller blades in the plurality of impeller blades and comprises a surface area that is greater than the surface area of any one of the remaining impeller blades in the plurality of impeller blades.

### Claim 5

A thrombus disruption and removal system, comprising:
a drive shaft defining a proximal end and a distal end and an axis of rotation;
a working region defined near, or at, the distal end of the drive shaft, the working region comprising:
an impeller hub defining a wall and attached to and/or surrounding the drive shaft;
a plurality of impeller blades attached to, or integrated with, the impeller hub and extending radially therefrom, wherein the impeller blades are shaped so as to draw tissue during rotation of the impeller hub proximally from a thrombus;
at least a portion of the drive shaft engaging the impeller hub and extending at least partially through a lumen defined through the impeller hub;
a prime mover coupled to the proximal end of the drive shaft and, together with the drive shaft, configured to rotate the impeller hub and to translate the working region,
wherein at least one of the impeller blades comprises a surface area that is greater than the surface area of any one of the remaining impeller blades in the plurality of impeller blades.

### Claim 6 (depends on 5)

The thrombus disruption and removal system of claim 5, further comprising a catheter having a proximal end and a distal end and a lumen within which the drive shaft is rotatable and translatable, wherein the impeller blades, when rotated, further aspirate the tissue from the thrombus within the lumen of the catheter.