# US 12,213,481 B1 · 4,4′-[(2-hydroxypropane-1,3-diyl)bis(oxy)]dibenzaldehyde as an eco-friendly insecticidal agent against Spodoptera littoralis (boisd.)

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- Number: US 12,213,481 B1
- Document ID: US12213481B1
- Status: Granted
- Kind: B1
- Application number: 18/655,571
- Filed: 2024-05-06
- Granted: 2025-02-04
- Earliest claimed: 2023-12-29
- Assignees: King Faisal University
- Applicants: King Faisal University
- Inventors: Hany Mohamed Abd El-Lateef Ahmed; Mai Mostafa Khalaf Ali; Mohamed Gouda; Antar Ahmed Abdelhamid Ahmed; Mohamed A. Gad
- Web page: https://patentgrep.com/patent/US12213481B1

## CPC

- A01N 35/04: containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
- A01P 7/04: Insecticides
- A01P 17/00: Pest repellants
- C07C 47/575: containing ether groups, [IMAGE cpc-sch-C07C-0958.gif] groups,[IMAGE cpc-sch-C07C-0959.gif] groups, or[IMAGE cpc-sch-C07C-0960.gif] groups
- C07C 2601/16: the ring being unsaturated
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01P: BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

Synthesis of a compound 4,4′-[(2-hydroxypropane-1,3-diyl)bis(oxy)]dibenzaldehyde and its use as an insecticidal agent.

## Claims

### Claim 1

A method of killing insects comprising applying to said insects or to a target site of insect infestation an insecticidally effective amount of an insecticidally active composition comprising an insecticidally effective amount of a 4,4′-[(2-hydroxypropane-1,3-diyl)bis(oxy)]dibenzaldehyde compound having the formula I:
and an insecticidally acceptable carrier.

### Claim 2 (depends on 1)

The method of killing insects of claim 1, wherein the insects belong to a species Spodoptera littoralis.

### Claim 3 (depends on 2)

The method of killing insects of claim 2, wherein the 4,4′-[(2-hydroxypropane-1,3-diyl)bis(oxy)]dibenzaldehyde compound has an LC50 of about 25.62 mg/L against the species Spodoptera littoralis after 72 hours of treatment.

### Claim 4 (depends on 2)

The method of killing insects of claim 2, wherein 4,4′-[(2-hydroxypropane-1,3-diyl)bis(oxy)]dibenzaldehyde compound has an LC50 of about 25.62 mg/L ppm against 2nd instars of larvae of the species Spodoptera littoralis after 72 hours of treatment.

### Claim 5 (depends on 2)

The method of killing insects of claim 2, wherein the 4,4′-[(2-hydroxypropane-1,3-diyl)bis(oxy)]dibenzaldehyde compound has an LC50 of about 86.13 mg/L against the species Spodoptera littoralis after 72 hours of treatment.

### Claim 6 (depends on 2)

The method of killing insects of claim 2, wherein the 4,4′-[(2-hydroxypropane-1,3-diyl)bis(oxy)]dibenzaldehyde compound has an LC50 of about 86.13 mg/L ppm against 4th instars of larvae of the species Spodoptera littoralis after 72 hours of treatment.

### Claim 7 (depends on 1)

The method of killing insects of claim 1, wherein the 4,4′-[(2-hydroxypropane-1,3-diyl)bis(oxy)]dibenzaldehyde compound is applied to castor leaves.

### Claim 8 (depends on 1)

The method of killing insects of claim 1, wherein about 12.5 to about 200 ppm of the 4,4′-[(2-hydroxypropane-1,3-diyl)bis(oxy)]dibenzaldehyde compound is applied to the insects or to the target site.

### Claim 9

A method of repelling insects comprising applying to a target site of insect infestation an insect repelling effective amount of an insecticidally active composition comprising an insect repelling effective amount of a 4,4′-[(2-hydroxypropane-1,3-diyl)bis(oxy)]dibenzaldehyde compound having the formula I:
and an insecticidally acceptable carrier.

### Claim 10 (depends on 9)

The method of repelling insects of claim 9, wherein the insects belong to a species Spodoptera littoralis.

### Claim 11 (depends on 9)

The method of repelling insects of claim 9, further comprising controlling an insect pest comprising applying to a target site of insect infestation an insect controlling effective amount of the insecticidally active composition.

### Claim 12 (depends on 11)

The method of claim 11, wherein the insect pest belongs to a species Spodoptera littoralis.