Factor IX encoding nucleotides
AssigneeUCL Business PLC
InventorsAmit Nathwani, Jenny Mcintosh
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Abstract
The present invention relates to polynucleotides comprising a Factor IX nucleotide sequence, wherein the Factor IX nucleotide sequence comprises a coding sequence that encodes a Factor IX protein or fragment thereof and wherein a portion of the coding sequence is not wild type. The present invention further relates to viral particles comprising a recombinant genome comprising the polynucleotide of the invention, compositions comprising the polynucleotides or viral particles, and methods and uses of the polynucleotides, viral particles or compositions.
Claims20
A polynucleotide comprising a Factor IX nucleotide sequence, wherein the Factor IX nucleotide sequence encodes a Factor IX protein and has at least 90% identity to SEQ ID NO. 5 and wherein the Factor IX nucleotide sequence comprises a codon that encodes leucine at a position corresponding to position 384 of wild type Factor IX, wherein the wild type Factor IX is encoded by SEQ ID NO:
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Dependencies are inferred from the claim text.