Bis-octahydrophenanthrene carboxamide derivatives and protein conjugates thereof for use as LXR agonists

A compound of Formula A, B, C, or D

• or a pharmaceutically acceptable salt, or stereoisomeric form thereof, wherein
• L is a linker;
• BA is an antibody or antigen binding fragment thereof;
• k ranges from about one to about thirty;
• each of Q1 and Q2 is independently —CH2—, —C(O)—, —C(H)(OH)—, C (OH)2—, —SO2—, —SO—, —PO(OR3)—, —PO(NR3NR4)—, —NR3—, or —N═;
• W is —CH2—, —N(H)—, or —O—;
• R1 is —N(H)R4, —N(H)R4—, —N(H)—, —N(R5)2, or —N(R5)2—;
• R2 is —N(H)R4, —N(H)R4—, or —N(H);
• each R4 is, independently in each instance, hydrogen, an amino acid residue, an N-alkyl amino acid residue, a peptide residue, a biodegradable moiety comprising aliphatic polyesters, alkyl, substituted alkyl, acyl, substituted acyl, or —alkylene-;
• R5 is alkyl, aryl, arylalkyl, heterocycloalkyl, or substituted heterocycloalkyl, wherein each heterocycloalkyl or substituted heterocycloalkyl comprises one, two, or three heteroatoms selected from nitrogen and oxygen, and when substituted includes at least one-OH and —CH2OH, or at least one primary or secondary nitrogen;
• each R6 is independently halo, C1-6 alkyl, C1-6 alkylene, C1-6 alkoxy, —CN, O-glucose, O-amino acid residue, or O-PEGn1, wherein each n is an integer from zero to fourteen, and each n1 is an integer from one to twelve;
• and
• each R3 is independently hydrogen, alkyl, or aryl.