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US 12,209,113 B2Granted
Methods and compositions for protection against lentiviral infections
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsMatthew Gardner, Michael Farzan
Life of this patent
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Abstract
The present invention provides methods and compositions for optimally co-expressing in a primate subject a tyrosylprotein sulfotransferase (TPST) and a lentiviral gp120-binding molecule to provide potent and long term protection against lentiviral infections.
Claims15
A method of preventing a lentiviral viral infection in a subject at risk of developing or suffering from the lentiviral infection, comprising administering to the subject a prophylactically effective amount of:
- (a) a first polynucleotide sequence expressing a tyrosylprotein sulfotransferase (TPST), and
- (b) a second polynucleotide sequence expressing a fusion polypeptide comprising:
- (i) a CCR5 mimetic comprising SEQ ID NO:
- 21 that binds a gp120 protein of a primate lentivirus,
- (ii) a CD4 polypeptide having at least 90% sequence identity to SEQ ID NO:
- 3 or SEQ ID NO:
- 4, and
- (iii) an immunoglobulin Fc domain;
- wherein the molar ratio of the first polynucleotide sequence to the second polynucleotide sequence, or the molar ratio of the TPST expressed from the first polynucleotide sequence to the fusion polypeptide expressed from the second polynucleotide sequence, is at least 1:2;
- thereby preventing the viral infection in the subject.
7 more elements
Dependencies are inferred from the claim text.