Back to results
US 12,209,109 B2Granted
Method for preparing a composition comprising highly concentrated antibodies by ultrafiltration
AssigneesChugai Seiyaku Kabushiki Kaisha, Genentech, Inc.
InventorsKelby Lau, Jean Bender, Saeko Tanaka, Rumiko Wakayama, Hidenari Yamada, Tomonori Isoda, Masayoshi Oh-Eda
Life of this patent
Estimating the term…
Abstract
The present invention provides a method for preparing a composition comprising highly concentrated antibodies by ultrafiltration in batch concentration mode having a first constant feed rate step and a second controlled feed rate step.
Claims20
A method for preparing a composition comprising concentrated antibodies by ultrafiltration, wherein the method comprises concentrating an antibody preparation by ultrafiltrating the preparation, said ultrafiltrating comprising:
- (a) regulating a feed flow rate of the preparation to allow a value of feed pressure applied to an ultrafiltration membrane to increase to 85-100% of a specified maximum feed pressure of the ultrafiltration membrane;
- and
- (b) decreasing the feed flow rate to maintain or decrease the value of the feed pressure applied to the ultrafiltration membrane after the step (a),
- wherein the antibody preparation directly after said ultrafiltrating has an antibody concentration above 200 g/L or a viscosity above 10 mPa's and wherein the antibodies are tocilizumab.
1 more element
Dependencies are inferred from the claim text.