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US 12,209,060 B2Granted
Ketamine derivatives and compositions thereof
AssigneeXwpharma Ltd.
InventorsJia-Ning Xiang, Xuesong Xu, Hao-Wei Shih, Wai-Si Eng
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Abstract
Ketamine derivatives and pharmaceutical compositions thereof are disclosed. When administered orally the ketamine derivatives provide increased bioavailability of ketamine in the systemic circulation. The ketamine derivatives can be used to treat neurological diseases, psychological diseases and pain.
Claims24
A compound of Formula (1):
- or a pharmaceutically acceptable salt thereof, wherein,
- R1 is selected from hydrogen and C1-6 alkyl;
- and
- R2 is a moiety of Formula (6):
- wherein,
- p is an integer from 1 to 3;
- and
- each R8 is independently selected from hydrogen, C1-6 alkyl, and —NH2.
5 more elements
Dependencies are inferred from the claim text.