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US 12,208,189 B2Granted
Deactivation of circulating tumor cells (CTCs) in the bloodstream by electrostatic stimulation of the peripheral blood
AssigneeNano Hesgarsazan Salamat Arya
InventorsMohammad Abdolahad, Mohammad Reza Ghaderinia, Mohammad Ali Khayamian, Hamed Abadijoo, Shahriar Shalileh
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Abstract
A method for deactivating circulating cancer cells (CTCs). The method includes reducing viability of CTCs and/or destroying CTCs by applying a positive electrostatic field to bloodstream of a cancer patient.
Claims12
A system for deactivating circulating cancer cells (CTCs), comprising:
- a tubing line comprising a fluidic channel, the fluidic channel comprising a portion of the tubing line having a spiral u-shape with two ends, the two ends comprising an inlet and an outlet;
- at least two peristaltic pumps, configured to circulate a flow of bloodstream through the tubing line, the at least two peristaltic pumps comprising:
- a first peristaltic pump configured to:
- extract bloodstream of a cancer patient' body into the inlet of the fluidic channel;
- and
- pass the extracted bloodstream through the fluidic channel;
- and
- a second peristaltic pump configured to transmit the bloodstream from the outlet of the fluidic channel into the cancer patient's body:
- an electrically conductive element placed on the fluidic channel, the electrically conductive element configured to accumulate positive electrostatic charges thereon;
- an electrostatic charge generator electrically connected to the electrically conductive element, the electrostatic charge generator configured to apply a positive electrostatic voltage to the electrically conductive element;
- and
- a processing unit electrically connected to the electrostatic charge generator and the at least two peristaltic pumps, the processing unit comprising:
- a memory having processor-readable instructions stored therein;
- and
- a processor configured to access the memory and execute the processor-readable instructions, which, when executed by the processor configures the processor to perform a method, the method comprising:
- circulating a portion of the bloodstream of the cancer patient's body inside the fluidic channel utilizing the at least two peristaltic pumps:
- accumulating positive electrostatic charges on the electrically conductive element by applying the positive electrostatic voltage to the electrically conductive element utilizing the electrostatic charge generator;
- and
- forming deactivated CTCs in the circulating portion of the bloodstream by at least one of reducing viability of CTCs and destroying CTCs responsive to electrostatically stimulating of CTCs induced by the accumulated positive electrostatic charges.
16 more elements
Dependencies are inferred from the claim text.