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US 12,208,125 B2Granted
Stable dry powders and emulsions containing probiotics
AssigneeVirun, Inc.
InventorPhilip J. Bromley
Life of this patent
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Abstract
Compositions and methods for mucosal delivery of agents are provided. The emulsion compositions are intended for administration to a mucosal surface, such as oral, gastrointestinal and nasal mucosa. The emulsion compositions provided contain one or more mucoadhesive proteins and an agent to be delivered. Methods for delivery of agents using the compositions provided herein are also provided.
Claims21
An emulsion composition, comprising:
- a) a mucoadhesive protein associated with a probiotic, wherein:
- the mucoadhesive protein is present at a concentration of about or at 1%, by weight, up to about or at 10% of the total weight of the composition;
- the mucoadhesive protein is selected from among the family of transferrins and the family of mucin proteins;
- the probiotic is present at a concentration of about or at 1% to about or at 10%, by weight of the composition;
- the total concentration of mucoadhesive protein and probiotic is from about or at 2% to about or at 20%, by weight of the composition;
- and
- the mucoadhesive protein is associated with the proteins on the probiotic bacterial surface via a chemical and/or physical bond;
- b) a polar protic solvent in an amount between about or at 40% to 80%, by weight, of the composition;
- c) a consumable oil, in an amount between about or at 10%-20%, by weight, whereby the composition is formulated as an emulsion, wherein the composition does not include a PEG-derivative of vitamin E;
- and
- d) a surface active agent, other than a polyalkylene derivative of vitamin E.
8 more elements
Dependencies are inferred from the claim text.