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US 12,208,066 B2Granted
Methods of permeabilizing the blood brain barrier
AssigneeUniversity of Southern California
InventorThomas Chen
Life of this patent
Estimating the term…
Abstract
The present invention relates to using monoterpene or sesquiterpene to permeabilize the blood brain barrier.
Claims13
A method of treating a central nervous system (CNS) cancer, the method comprising administering to a mammal perillyl alcohol (POH) before or concurrently with a therapeutic agent that is a chimeric antigen receptor T-cell (CAR-T cell),
- wherein the POH and CAR-T cells are administered by intracardiac injection, and
- wherein the CNS cancer is a malignant glioma, pilocytic astrocytomas (grade I), meningiomas, metastatic brain tumors, or pituitary adenomas.
Dependencies are inferred from the claim text.