Identification of porcine xenoantigens
AssigneeIndiana University Research and Technology Corporation
InventorsBurcin Ekser, Ping Li
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Abstract
Provided herein are genetically modified pigs, porcine organs, tissue, and cells having a reduced propensity to cause a rejection response in a human subject following xenotransplantation. In particular, provided herein are genetically modified pigs lacking nonGal xenoantigens, and porcine cells, tissues, and organs obtained from such genetically modified pigs that are suitable for transplantation into a human. Also provided herein are methods of improving a rejection related symptom in a human subject.
Claims5
A genetically modified porcine cell, wherein the genetic modifications comprise modifications to the genome of the porcine cell that results in the lack of any expression of functional pCD37 (pCD37KO), wherein said genetically modified porcine cell exhibits reduced binding to human immunoglobulins IgG and IgM relative to a porcine cell lacking said genetic modifications.
Dependencies are inferred from the claim text.