Methods and materials for identifying and treating membranous nephropathy
AssigneeMayo Foundation for Medical Education and Research
InventorsM. Cristine Charlesworth, Sanjeev Sethi, Fernando C. Fervenza, Benjamin J. Madden
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Abstract
This document provides methods and materials involved in identifying and treating mammals (e.g., humans) having membranous nephropathy. For example, methods and materials for detecting the presence of autoantibodies specific for an EXT1 and/or EXT2 polypeptide as well as methods and materials for detecting the presence of kidney tissue having an elevated level of an EXT1 and/or EXT2 polypeptide are provided. In addition, methods and materials for treating membranous nephropathy by administering an immunosuppressant are provided.
Claims17
A method for treating a mammal having membranous nephropathy, wherein said method comprises administering an immunosuppressant to a mammal identified as having (i) autoantibodies specific for a polypeptide or (ii) kidney tissue comprising an elevated level of said polypeptide as compared to a level of said polypeptide in normal kidney tissue, wherein said polypeptide is an exostosin 1 (EXT1) polypeptide or an exostosin 2 (EXT2) polypeptide.
Dependencies are inferred from the claim text.