US 12,203,906 B2 · Dynamically adjusting set points for a heating/cooling element of a chromatography column using available information

Abstract

The exemplary embodiments may determine a temperature set point for an outlet heater or cooler based on available information without requiring user input or requiring only minimal user input. The exemplary embodiments may estimate the temperature set point of the outlet heater based on available information, such as pressure delta along the column, temperature at the inlet of the chromatography column, and volumetric flow rate. In some instances, the estimate may be normalized for column dimensions, such as length and diameter. Tailing factor may also be used in determining the estimate. The estimate is not computationally burdensome and can be recalculated as the chromatography column is in use.

Claims20

Dependent claims

A chromatography system, comprising:

a chromatography column having an inlet for receiving a mobile phase with an analyte and an outlet through which the mobile phase exits after flowing through the column;
an outlet heater or cooler positioned to heat or cool at the outlet of the chromatography column;
a controller for controlling an amount heating or cooling imparted by the heater or cooler, the controller configured for controlling the outlet heater or cooler to achieve a set point temperature for the outlet of the column, wherein the controller is configured to set the set point temperature for the outlet heater or cooler based on an estimate, wherein calculation of the estimate only requires values for a temperature at the inlet of the chromatography column, an offset value, an adjustment value, and a logarithmic function of a flow rate of the mobile phase and a pressure delta.

Dependencies are inferred from the claim text.

Dynamically adjusting set points for a heating/cooling element of a chromatography column using available information

Life of this patent

Dynamically adjusting set points for a heating/cooling element of a chromatography column using available information

Life of this patent

Abstract

Claims20