Fluorescence generating device and digital polymerase chain reaction analysis system including the same
AssigneeElectronics and Telecommunications Research Institute
InventorJin Tae Kim
Life of this patent
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Abstract
Provided are a fluorescence generating device and a digital PCR analysis system including the same. The fluorescence generating device includes a clad layer on a substrate, an optical waveguide arranged in a first direction within the clad layer, and a housing which is disposed on the optical waveguide and the clad layer and has a micro fluid channel extending in a second direction. The optical waveguide includes an input waveguide which is provided within one side of the clad layer and provides excitation light to a liquid drop within the micro fluid channel to generate fluorescent light, and an output waveguide which is provided within the other side of the clad layer and has an output inclined surface that reflects the fluorescent light.
Claims17
A fluorescence generating device comprising:
- a clad layer on a substrate;
- an optical waveguide disposed within the clad layer and arranged in a first direction;
- and
- a housing disposed on the optical waveguide and the clad layer, the housing having a micro fluid channel that extends in a second direction crossing the first direction,
- wherein the optical waveguide comprises:
- an input waveguide which is provided within one side of the clad layer and provides excitation light to a liquid drop within the micro fluid channel to generate fluorescent light;
- and
- an output waveguide which is provided within the other side of the clad layer, the output waveguide having an output inclined surface disposed between the micro fluid channel and the clad layer to reflect the fluorescent light,
- wherein the input waveguide is disposed below the micro fluid channel, the input waveguide having an input inclined surface disposed between the micro fluid channel and the clad layer to reflect the excitation light to the liquid drop within the micro fluid channel, and
- wherein the fluorescence generating device further comprises a reflection layer which is disposed between the input and output inclined surfaces and the clad layer.
A fluorescence generating device comprising:
- a clad layer on a substrate;
- an input waveguide provided on one side of the clad layer, the input waveguide having an input inclined surface;
- an output waveguide provided on the other side of the clad layer, the output waveguide having an output inclined surface adjacent to the input inclined surface;
- a reflection layer provided between the input and output inclined surfaces and the clad layer;
- a fluid chip disposed above the input inclined surface and the output inclined surface, the fluid chip having a micro fluid channel that accommodates oil and a liquid drop within the oil;
- an excitation light filter disposed within the micro fluid channel above the output inclined surface to remove excitation light provided to the liquid drop;
- and
- a fluorescent light filter disposed within the micro fluid channel adjacent to the input waveguide to remove fluorescent light discharged from the liquid drop by the excitation light.
A digital PCR analysis system comprising:
- a light source device including an exciting light source configured to generate excitation light;
- a fluorescence generating device configured to receive the excitation light to generate fluorescent light of a liquid drop;
- and
- a detection device provided with a photo-detector configured to detect the fluorescent light,
- wherein the fluorescence generating device comprises:
- a clad layer on a substrate;
- an optical waveguide disposed within the clad layer and arranged in a first direction;
- and
- a housing disposed on the optical waveguide and the clad layer, the hosing having a micro fluid channel that extends in a second direction crossing the first direction,
- wherein the optical waveguide comprises:
- an input waveguide provided within one side of the clad layer, the input waveguide providing the excitation light to the liquid drop within the micro fluid channel to generate the fluorescent light;
- and
- an output waveguide provided within the other side of the clad layer, the output waveguide having an output inclined surface that is disposed between the micro fluid channel and the clad layer to reflect the fluorescent light,
- wherein the input waveguide is disposed below the micro fluid channel, the input waveguide having an input inclined surface disposed between the micro fluid channel and the clad layer to reflect the excitation light to the liquid drop within the micro fluid channel, and
- wherein the fluorescence generating device further comprises a reflection layer which is disposed between the input and output inclined surfaces and the clad layer.
Dependencies are inferred from the claim text.