Method of producing sulfur-containing amino acid or derivative thereof
AssigneeCj Cheiljedang Corporation
InventorsSol Choi, Hee Ju Kim, Jin Ah Rho, Jin Nam Lee, Han Hyoung Lee, Sun Young Lee, Sang Jun Kim, Jihyun Shim
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Abstract
A method of producing sulfur-containing amino acids or derivatives of the sulfur-containing amino acids.
Claims12
A method of producing a sulfur-containing amino acid or a derivative of the sulfur-containing amino acid, the method comprising culturing a genetically modified microorganism in a culture medium including thiosulfate,
- wherein the microorganism includes genetic modification to increase an expression level of a protein encoded by ssuABC gene compared to a non-modified microorganism,
- wherein the protein encoded by ssuABC gene is a complex of SsuA, SsuB, and SsuC proteins, and wherein the sulfur-containing amino acid or the derivative of the sulfur-containing amino acid is selected from the group consisting of methionine, cysteine, cystine, lanthionine, homocysteine, homocystine, homolanthionine, and taurine, and
- wherein the microorganism has an increase in an expression level of at least one protein selected from the group consisting of SsuA, SsuB, and SsuC proteins compared to a non-modified microorganism.
A microorganism producing a sulfur-containing amino acid or a derivative of the sulfur-containing amino acid and including genetic modification to increase an expression level of a protein encoded by ssuABC gene compared to a non-modified microorganism, wherein the protein encoded by ssuABC gene is a complex of SsuA, SsuB, and SsuC proteins, and wherein the sulfur-containing amino acid or the derivative of the sulfur-containing amino acid is selected from the group consisting of methionine, cysteine, cystine, lanthionine, homocysteine, homocystine, homolanthionine, and taurine, and wherein the microorganism produces the sulfur-containing amino acid or the derivative of the sulfur-containing amino acid using thiosulfate as a sulfur source.
A composition for producing a sulfur-containing amino acid or a derivative of the sulfur-containing amino acid,
- wherein the composition comprises:
- a microorganism including genetic modification to increase an expression level of a protein encoded by ssuABC gene compared to a non-modified microorganism, or a culture thereof;
- and thiosulfate;
- wherein the protein encoded by ssuABC gene is a complex of SsuA, SsuB, and SsuC proteins, and wherein the sulfur-containing amino acid or the derivative of the sulfur-containing amino acid is selected from the group consisting of methionine, cysteine, cystine, lanthionine, homocysteine, homocystine, homolanthionine, and taurine.
Dependencies are inferred from the claim text.