Flavonoid and anthocyanin bioproduction using microorganism hosts
AssigneeDebut Biotechnology, Inc.
InventorsJingyi Li, Nicholas Brideau, Joshua Britton, Erik Holtzapple
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Abstract
The invention is directed to methods involved in the production of flavonoids, anthocyanins and other organic compounds. The invention provides cells engineered for the production of flavonoids, anthocyanins and other organic compounds, where the engineered cells include one or more genetic modifications that increase flavonoid production by increasing metabolic flux to flavonoid precursors and/or reducing carbon losses resulting from the production of byproducts.
Claims10
An engineered host cell, wherein the engineered host cell comprises one or more genetic modifications to an endogenous gene to increase the production and/or availability of malonyl-CoA in comparison to a wild-type host cell, wherein the engineered host cell expresses acetyl-CoA carboxylase (ACC) having an amino acid sequence at least 85% identical to the polypeptide set forth in SEQ ID NO:
- 15.
Dependencies are inferred from the claim text.