Programmable epigenetic control of gene expression in plants
AssigneeDecibel Bio, Inc
InventorsTravis Bayer, Kevin L. Schneider, Aden Kinne, Jennifer Adele Samson, Itxaso Garay
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Abstract
Disclosed herein are artificially synthesized nucleic acid constructs to guide an epigenetic modification for at least partially silencing or activating a target gene in an organism such as a plant or seed, and formulations thereof. Also disclosed are methods of applying such nucleic acid constructs to the plant or to the seed. Also disclosed are engineered seeds and plants obtained by the epigenetic modification.
Claims14
A double stranded artificial nucleic acid construct comprising (a) a first strand and a second strand each having a length of 20 to 30 nucleotides or nucleosides or a combination thereof;
- and (b) a terminal end overhang at one or both of a 3′ end of the first strand or a 3′ end of the second strand;
- wherein one or both of the 3′ terminal end overhangs comprise a ribose unit having a methoxy group (—O-Me) at a 2′ position;
- and
- wherein at least 80% of the sugars in the double stranded artificial nucleic acid construct comprises a deoxyribose, and wherein the nucleic acid construct does not comprise a regulatory element.
Dependencies are inferred from the claim text.