Plant viral RNA delivery nanoparticles and uses thereof
AssigneeCase Western Reserve University
InventorNicole F. Steinmetz
Life of this patent
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Abstract
A nanoparticle includes an icosahedral-shaped plant virus particle; an RNAi construct; and one or more endolysosomal release agents, wherein the RNAi construct is noncovalently loaded within the icosahedral-shaped plant virus particle.
Claims11
A nanoparticle comprising a cowpea chlorotic mottle virus (CCMV);
- a siRNA;
- and an L17E M-lycotoxin peptide, wherein the siRNA is noncovalently loaded within the CCMV.
A method of treating hormone dependent breast cancer in a subject, comprising administering to the subject a therapeutically effective amount of a nanoparticle including a cowpea chlorotic mottle virus (CCMV), an siRNA targeting the forkhead box transcription factor (FOXA1) oncogene, and a L17E M-lycotoxin peptide, wherein the RNAi construct is encapsulated within the CCMV.
A method of treating hormone dependent breast cancer in a subject, comprising administering to the subject a therapeutically effective amount of nanoparticle comprising a cowpea chlorotic mottle virus (CCMV) virus particle, an siRNA targeting the forkhead box transcription factor (FOXA1) oncogene, wherein the siRNA is encapsulated within the CCMV virus particle, and one or more endolysosomal release agents comprising a L17E M-lycotoxin peptide.
Dependencies are inferred from the claim text.