Eradication of bacterial biofilm using anti-amyloid monoclonal antibodies
AssigneesTemple University of the Commonwealth System of Higher Education, Lankenau Institute of Medical Research
InventorsCagla Tukel Wilson, Scott Dessain
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Abstract
The present invention features compositions comprising an anti-amyloid antibody and methods of treating microbial infection and treating or preventing microbial biofilms using the composition.
Claims14
An antibody or antibody fragment thereof comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO:9;
- a heavy chain CDR2 comprising amino acid sequence of SEQ ID NO:13;
- a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:17;
- a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 39;
- a light chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 43;
- and a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 47.
An isolated polypeptide comprising the amino acid sequence SEQ ID NO:9, SEQ ID NO:13, SEQ ID NO:17, SEQ ID NO:39, SEQ ID NO:
- 43, and SEQ ID NO:47.
An antibody or antibody fragment thereof comprising a heavy and light chain selected from the group consisting of:
- a) a heavy chain amino acid sequence comprising SEQ ID NO:2 and a light chain amino acid sequence comprising SEQ ID NO:35;
- b) a heavy chain amino acid sequence comprising SEQ ID NO:61 and a light chain amino acid sequence comprising SEQ ID NO:63;
- and
- c) a heavy chain amino acid sequence comprising SEQ ID NO:57 and a light chain amino acid sequence comprising SEQ ID NO:59.
An antibody or antibody fragment thereof comprising a heavy chain CDR1, wherein the heavy chain CDR1 comprises amino acid residues 23-35 of SEQ ID NO:
- 57;
- a heavy chain CDR2, wherein the heavy chain CDR2 comprises amino acid residues 50-59 of SEQ ID NO:
- 57;
- a heavy chain CDR3, wherein the heavy chain CDR3 comprises amino acid residues 97-116 of SEQ ID NO:
- 57;
- a light chain CDR1, wherein the light chain CDR1 comprises amino acid residues 24-34 of SEQ ID NO:
- 59;
- a light chain CDR2, wherein the light chain CDR2 comprises amino acid residues 49-56 of SEQ ID NO:
- 59;
- and a light chain CDR3, wherein the light chain CDR3 comprises amino acid residues 89-97 of SEQ ID NO:
- 59.
An antibody or antibody fragment thereof comprising a heavy chain CDR1, wherein the heavy chain CDR1 comprises amino acid residues 23-35 of SEQ ID NO:
- 61;
- a heavy chain CDR2, wherein the heavy chain CDR2 comprises amino acid residues 50-59 of SEQ ID NO:
- 61;
- a heavy chain CDR3, wherein the heavy chain CDR3 comprises amino acid residues 97-118 of SEQ ID NO:
- 61, a light chain CDR1, wherein the light chain CDR1 comprises amino acid residues 24-34 of SEQ ID NO:
- 63;
- a light chain CDR2, wherein the light chain CDR2 comprises amino acid residues 49-56 of SEQ ID NO:
- 63;
- and a light chain CDR3, wherein the light chain CDR3 comprises amino acid residues 89-97 of SEQ ID NO:
- 63.
Dependencies are inferred from the claim text.