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US 12,202,886 B2Granted
Neutralizing antibodies to GP120 and their use
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsMark Connors, Jinghe Huang, Byong Ha Kang, John Mascola, Elise Ishida, Tongqing Zhou, Peter Kwong, Anqi Zheng
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Abstract
Antibodies and antigen binding fragments that specifically bind to gp120 and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
Claims11
An isolated monoclonal antibody, comprising
- a heavy chain variable region (VH) comprising the amino acid sequence of SEQ ID NO:
- 1;
- a light chain variable region (VL) comprising the amino acid sequence of SEQ ID NO:
- 2;
- and
- an IgG constant domain comprising M428L and N434S mutations, wherein the antibody binds to CD4 binding site on HIV-1 gp120.
3 more elements
Dependencies are inferred from the claim text.