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US 12,202,863 B2Granted
Chimeric antigen receptor (CAR) modulation
AssigneeTrustees of Boston University
InventorsJohn Ngo, Wilson Wong, Meng Lai Nicole Wong, Huishan Li, Elliot P. Tague
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Abstract
The technology described herein is directed to CAR polypeptides and systems comprising repressible proteases. In combination with a specific protease inhibitor, the activity of said CAR polypeptides and systems and cells comprising them can be modulated. Also described herein are methods of using said CAR polypeptides and systems, for example to treat various diseases and disorders.
Claims20
A polypeptide system comprising:
- a) a first polypeptide comprising:
- (i) an extracellular binding domain;
- (ii) a transmembrane domain;
- and
- (iii) a reader domain comprising a danoprevir/NS3 complex reader domain (DNCR) or a grazoprevir/NS3 reader complex (GNCR) domain;
- and
- b) a second polypeptide comprising:
- (i) a repressible protease comprising hepatitis C virus (HCV) nonstructural protein 3 (NS3) genotype 1B comprising a sequence selected from the group consisting of SEQ ID NO:
- 99, SEQ ID NO:
- 130, and SEQ ID NO:
- 180;
- and
- (ii) at least one intracellular signaling domain.
10 more elements
Dependencies are inferred from the claim text.