MCL1 inhibitors

A compound of Formula (II):

• or a pharmaceutically acceptable salt thereof, wherein:
• Z1 is selected from CR1a, or N;
• Z2 is selected from CR2aR2b, S, NR2c, and O;
• wherein each R1a, R2a, and R2b is independently selected from hydrogen, halo, C1-6alkyl, C1-6alkoxyl, C1-6haloalkyl, and C1-6haloalkoxyl;
• and
• wherein R2c is independently selected from hydrogen, C1-6alkyl, and C1-6haloalkyl;
• wherein R16 is 3-12 membered heterocyclyl or 5-12 membered heteroaryl;
• wherein R16 is optionally substituted with 1-5 RA;
• R2 is selected from hydrogen, halo, C1-6alkyl, C1-6haloalkyl, C1-6alkoxyl, and —C1-4alkylene-O—C1-6alkyl;
• R3 is selected from hydrogen, halo, C1-6alkyl, C1-6haloalkyl, C1-6alkoxyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, and —C1-4alkylene-O-5-10 membered heteroaryl;
• wherein each C1-6alkyl, C1-6haloalkyl, C1-6alkoxyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, and —C1-4alkylene-O-5-10 membered heteroaryl of R3 is optionally substituted with one to four groups independently selected from halo, C1-6alkyl, C1-6haloalkyl, and C1-6alkoxyl;
• each R4 and R5 is independently selected from hydrogen, halo, hydroxyl, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C1-6alkoxyl, C1-6haloalkoxyl, —NRaaRbb, —NHC(O)—C1-6alkyl, —C(O)NH—C1-6alkyl, —O—C2-6alkynyl, —OC(O)—C1-6alkyl, —O—(CH2CH2O)n—C1-6alkyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, —O—C3-10cycloalkyl, —O—3-12 membered heterocyclyl, —O—C1-4alkylene-C3-10cycloalkyl, 5-10 membered heteroaryl, —O—C1-4alkylene-3-12 membered heterocyclyl, —O—5-10 membered heteroaryl, and —O—C1-4alkylene-5-10 membered heteroaryl;
• wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C1-6alkoxyl, C1-6haloalkoxyl, —NHC(O)—C1-6alkyl, —C(O)NH—C1-6alkyl, —O—C2-6alkynyl, —OC(O)—C1-6alkyl, —O—(CH2CH2O)n—C1-6alkyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, —O—C3-10cycloalkyl, —O—3-12 membered heterocyclyl, —O—C1-4alkylene-C3-10cycloalkyl, 5-10 membered heteroaryl, —O—C1-4alkylene-3-12 membered heterocyclyl, —O—5-10 membered heteroaryl, and —O—C1-4alkylene-5-10 membered heteroaryl of R4 and R5 is optionally substituted with one to four groups independently selected from halo, hydroxyl, oxo, C1-6alkyl, C1-6alkoxyl, C1-6haloalkoxyl, —NRaaRbb, C3-10cycloalkyl, and 3-12 membered heterocyclyl;
• each R6 and R7 is independently selected from hydrogen, halo, hydroxyl, C1-6alkyl, C1-6alkoxyl, C1-6haloalkyl, and C1-6haloalkoxyl;
• R8 is selected from hydrogen, halo, hydroxyl, oxo, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxyl, —O—C2-6alkenyl, —O—C2-6alkynyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl, —O—C3-10cycloalkyl, —O—3-12 membered heterocyclyl, —O—C6-10aryl, —O—5-10 membered heteroaryl, —O—C1-4alkylene-C3-10cycloalkyl, —O—C1-4alkylene-3-12 membered heterocyclyl, —O—C1-4alkylene-C6-10aryl, and —O—C1-4alkylene-5-10 membered heteroaryl;
• R9 is absent or selected from hydrogen, halo, hydroxyl, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxyl, —O—C2-6alkenyl, —O—C2-6alkynyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl, —O—C3-10cycloalkyl, —O—3-12 membered heterocyclyl, —O—C6-10aryl, —O—5-10 membered heteroaryl, —O—C1-4alkylene-C3-10cycloalkyl, —O—C1-4alkylene-3-12 membered heterocyclyl, —O—C1-4alkylene-C6-10aryl, and —O—C1-4alkylene-5-10 membered heteroaryl;
• wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxyl, —O—C2-6alkenyl, —O—C2-6alkynyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl, —O—C3-10cycloalkyl, —O—3-12 membered heterocyclyl, —O—C6-10aryl, —O—5-10 membered heteroaryl, —O—C1-4alkylene-C3-10cycloalkyl, —O—C1-4alkylene-3-12 membered heterocyclyl, —O—C1-4alkylene-C6-10aryl, and —O—C1-4alkylene-5-10 membered heteroaryl of R8 and R9 is independently optionally substituted with 1-5 RA;
• R10 is selected from hydrogen, halo, hydroxyl, —CN, C1-6alkyl, C1-6alkoxyl, C1-6haloalkyl, and C1-6haloalkoxyl;
• each R11, R12, R13, and R14 is independently selected from hydrogen, halo, hydroxyl, —CN, C1-6alkyl, C1-6alkoxy, and C1-6haloalkyl;
• or
• R11 and R13 together with the atoms to which they are attached form a C3-6 cycloalkyl or 3-6 membered heterocyclyl;
• wherein the 3-6 membered heterocyclyl has one to three heteroatoms;
• and wherein each C3-6 cycloalkyl and 3-6 membered heterocyclyl is optionally substituted with one to three groups independently selected from halo, hydroxyl, —CN, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, and C1-6haloalkoxyl;
• each RA is independently selected from halo, hydroxyl, oxo, —CN, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxyl, C1-6haloalkyl, C1-6haloalkoxyl, —C1-4alkylene-O—C1-4alkyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl, and —NRaaRbb;
• wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxyl, C1-6haloalkyl, C1-6haloalkoxyl, —C1-4alkylene-O—C1-4alkyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl of RA is independently substituted with one to three groups independently selected from halo, hydroxyl, —CN, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl, and —NRaaRbb;
• each Raa and Rbb is independently selected from hydrogen, C1-6alkyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl, —C1-6alkylene-C3-10cycloalkyl, —C1-6alkylene-3-12 membered heterocyclyl, —C1-6alkylene-C6-10aryl, and —C1-6alkylene-5-10 membered heteroaryl;
• wherein each C1-6alkyl, C3-10cycloalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl, —C1-6alkylene-C3-10cycloalkyl, —C1-6alkylene-3-12 membered heterocyclyl, —C1-6alkylene-C6-10aryl, and —C1-6alkylene-5-10 membered heteroaryl of Raa and Rbb is independently optionally substituted with one to four groups independently selected from halo, C1-6alkyl, —CN, C1-6alkoxyl, and C1-6haloalkyl;
• wherein the 3-12 membered heterocyclyl is a single ring or multiple rings having one to four heteroatoms independently selected from nitrogen, sulfur, phosphorus, —N(O)—, —S(O)—, and —S(O)2—;
• and wherein the multiple rings may be fused, bridged, or spiro;
• and
• wherein the 5-10 membered heteroaryl is an aromatic group having a single ring or multiple rings;
• wherein the 5-10 membered heteroaryl contains one to four heteroatoms independently selected from nitrogen, oxygen, sulfur, —N(O)—, —S(O)—, and —S(O)2.