Therapeutic agents for enhancing epithelial and/or endothelial barrier function

A compound of Formula (I)

• or a pharmaceutically acceptable salt or solvate thereof, wherein:
• each R1 is independently selected from the group consisting of OH, NO2, Halo, CF3, NR3R4, (C1-C6) alkoxy, —C(O)(C1-C6) alkyl, and —C(O)O(C1-C6) alkyl;
• each R2 is a substituent other than OH;
• R3 and R4 each is independently selected from the group consisting of H, alkyl, alkenyl, alkoxy, cycloalkyl, heterocyclo, aryl, heteroaryl, and R3 and R4 together with the carbon to which they are attached form a (C3-C8) cycloalkyl or (C3-C8) heterocyclo;
• X1 and X2 are each independently C or N, with proviso that X1 and X2 cannot be both C;
• X3 is O or S;
• m is an integer in the range of 1 to 4;
• and
• n is an integer in the range of 1 to 4,
• wherein R2 is Halo and m is 1 or 2;
• or wherein X1 and X2 are each N.