US 12,202,802 B2Granted

Styryl quinolinium, process for their preparation and use thereof as fluorescent probes for imaging

AssigneeBar-Ilan University

InventorsBilha Fischer, Abed Elhady Saady, Yaron Shav-Tal, Eli Varon

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Abstract

The present invention is directed to styryl quinolinium compounds, a process for their synthesis and their use for selective nucleoli staining in cells, preferably in living cells and for imaging rRNA.

Claims2

Dependent claims

The compound (E)-2-(3, 5-Difluoro-4-hydroxystyryl)-1-methylquinolinium iodide (I-e).

Dependencies are inferred from the claim text.

Facts

Application: 17/507,028Filed 21 Oct 2021 · us provisional application
Priority: 21 Oct 2020
Published: US 2022/0119349 A121 Apr 2022
Granted: 21 Jan 2025
Term ends: Not estimatedThe source records don’t support an estimate.

Classification9 codes

C07D 215/10
With only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms: quaternary compounds
C07D 215/12
Having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring…:…
C07D 215/14
With substituted hydrocarbon radicals attached to ring carbon atoms: radicals substituted by oxygen atoms
G01N 1/30
Preparing specimens for investigation including physical details of chemical methods covered elsewhere, e.g. G01N33/50, C12Q: staining;…

Family

Application63/094,360Us provisional application · filed 21 Oct 2020
US 2022/0119349 A1Pre-grant publication · published 21 Apr 2022
US 12,202,802 B2This patent

From the US filing history. Foreign family members aren’t listed.

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