Sulfonamide derivatives having selective Nox inhibiting activity

A compound of formula (Ia)

• or a pharmaceutically acceptable salt thereof, wherein
• m is 1;
• n is an integer of from 3 to 5;
• each R1 is independently selected from C1-C6 alkyl, C3-C6 carbocyclyl, C3-C6 carbocyclyl-C1-C3 alkyl, C1-C6 alkoxy, C1-C6 alkoxy-C1-C3 alkyl, C3-C6 carbocyclyloxy, C3-C6 carbocyclyloxy-C1-C3 alkyl, 4- to 6-membered heterocyclyl, 4- to 6-membered heterocyclyl-C1-C3 alkyl, hydroxy, hydroxy-C1-C3 alkyl, Cl, and Br;
• and when n is at least 4, two R1 attached to adjacent atoms of the phenyl ring, together with the phenyl ring atoms to which they are attached, may form a 4- to 6-membered non-aromatic ring optionally containing one or more heteroatoms and optionally substituted with one or more moieties independently selected from C1-C3 alkyl and halogen;
• one R1a is halogen, and the other R1a is selected from C1-C6 alkyl, C1-C6 alkoxy, hydroxy, and halogen;
• R2 is selected from C1-C3 alkyl, halogen, hydroxy, and hydroxy-C1-C3 alkyl;
• R3, R4, R5, and R6 are independently selected from H and F;
• any alkyl is optionally substituted with one or more halogens;
• and
• any carbocyclyl or heterocyclyl is optionally substituted with one or more moieties independently selected from halogen and C1-C3 alkyl.