Method for 3D-micro-patterning

A method of manufacturing pharmaceutical solid dosage forms comprising the steps of:

• feeding at least one of each active ingredient and excipient into the extrusion channel of at at least one first extruder, said channel terminating at least one exit port, said exit port having at least a valve, said valve mated to at least one input port of at least one second extruder;
• mixing and heating the active ingredient and excipient to form a plasticized matrix;
• conveying said plasticized matrix to said first extruder's exit port using at least a rotatable screw;
• extruding the conveyed plasticized matrix through said exit port and valve, thereby filling at least one extrusion channel of at least one second extruder with said extruded plasticized matrix, said second extruder channel terminating at at least one fiber fabrication exit port;
• extruding the plasticized matrix in said second extruder extrusion channel through said fiber fabrication port at a controlled speed using an advancing piston driven by an electric motor;
• and depositing the extruded plasticized fiber onto a fiber assembling stage to a form a three dimensional fiber structural framework defined by the motion of said stage at the speed of the exiting extruded, plasticized fiber;
• wherein the three dimensional fiber structural framework is used in a pharmaceutical solid dosage form.

A method of manufacturing pharmaceutical solid dosage forms comprising the steps of:

• feeding at least one of each active ingredient, excipient, and solvent into the extrusion channel of at least one first extruder, said channel terminating at at least one exit port, said exit port having at least a check valve, and said at least one exit port mated to at least one input port of at least one second extruder;
• mixing the active ingredient, excipient, and solvent to form a plasticized matrix;
• conveying said plasticized matrix to said first extruder's exit port using at least a rotatable screw;
• extruding the conveyed plasticized matrix through said exit port, thereby filling at least one extrusion channel of at least one second extruder with said extruded plasticized matrix, said second extruder channel terminating at at least one fiber fabrication exit port;
• extruding the plasticized matrix in said second extruder extrusion channel through said fiber fabrication exit port at a controlled speed using an advancing piston driven by an electric motor;
• and depositing the extruded plasticized fiber onto a fiber assembling stage to a form a three dimensional fiber structural framework defined by the motion of said stage at the speed of the exiting extruded, plasticized fiber;
• wherein the three dimensional fiber structural framework is used in a pharmaceutical solid dosage form.