Pharmaceutical composition comprising GHB gastro-retentive raft forming systems having trigger pulse drug release

An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses, the composition comprising:

• (a) at least one drug in a first pulse which releases in less than about 3 hours;
• (b) at least one drug in a delayed trigger release form;
• (c) at least one non-toxic gas generating agent;
• and
• (d) a RAFT system, and
• wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one drug in the stomach for at least about 3 hours,
• wherein the RAFT is a liquid crystal RAFT comprising a cubic phase-forming lipid
• wherein the at least one drug of (a) and (b) is an active pharmaceutical ingredient (API) which is a free base or acid, or a pharmaceutically acceptable salt, solvate or hydrate, thereof,
• wherein the at least one drug comprises a gamma hydroxybutyrate or its salts, hydrates, tautomers, or solvates, or mixtures thereof,
• wherein the at least one delayed trigger release form of (b) comprises a pH sigmoidal delayed trigger system, an erosion delayed trigger system, a pH plus swelling delayed trigger system or a swelling delayed trigger system.