Hydroxyapatite, cosmetic, food, and method for producing the same
AssigneeBrainy Inc.
InventorsHideki Aoki, Nobukiyo Tanaka
Life of this patent
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Abstract
According to the present invention, provided is a carbonate- and magnesium-substituted hydroxyapatite having a particle size of 5 nm or more and 60 nm or less, wherein a portion of the calcium atoms in the hydroxyapatite are substituted with magnesium atoms and a portion of phosphate groups are substituted with carbonate groups.
Claims4
A method for producing a suspension comprising carbonate- and magnesium-substituted hydroxyapatite having a part of calcium substituted with magnesium and a part of phosphate group substituted with a carbonate group, and comprising primary particles in a non-aggregated state, the primary particles having a particle size of 5 nm or more and 60 nm or less,
- the method comprising:
- preparing a mixed suspension comprising magnesium hydroxide and calcium hydroxide;
- preparing a phosphoric acid aqueous solution;
- and
- mixing the mixed suspension and the phosphoric acid aqueous solution by stirring in the presence of pure carbon dioxide gas, causing a neutralization reaction, and obtaining, in a liquid state, the suspension comprising the carbonate- and magnesium-substituted hydroxyapatite comprising the primary particles in the non-aggregated state.
A method for producing a suspension comprising carbonate- and magnesium-substituted hydroxyapatite having a part of calcium substituted with magnesium and a part of phosphate group substituted with a carbonate group, and comprising primary particles in a non-aggregated state, the primary particles having a particle size of 5 nm or more and 60 nm or less,
- the method comprising:
- preparing a first solution comprising magnesium salt and calcium salt;
- preparing a second solution comprising phosphate salt;
- and
- mixing the first solution and the second solution by stirring in the presence of pure carbon dioxide gas, causing a reaction, and obtaining, in a liquid state, the suspension comprising the carbonate- and magnesium-substituted hydroxyapatite comprising the primary particles in the non-aggregated state.
Dependencies are inferred from the claim text.