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US 12,201,659 B2Granted
Foamy viruses and methods of use
AssigneeMayo Foundation for Medical Education and Research
InventorsYasuhiro Ikeda, Karol M. Budzik, Stephen James Russell
Life of this patent
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Abstract
This document provides methods and materials for treating cancer. For example, foamy viruses (e.g., simian foamy viruses) are provided as well as methods and materials for treating cancer using foamy viruses as an oncolytic agent.
Claims5
A chimeric simian foamy virus (SFV) comprising:
- (a) a first genomic fragment comprising a 5′ LTR, a nucleic acid encoding a gag polypeptide, and a 5′ portion of a nucleic acid encoding a pol polypeptide of a chimpanzee PAN1 SFV strain;
- (b) a second genomic fragment comprising a 3′ portion of a nucleic acid encoding a pol polypeptide, a nucleic acid encoding an env polypeptide, a nucleic acid encoding a tas polypeptide, a nucleic acid encoding a bel2 polypeptide, and a 3′ LTR of a chimpanzee PAN2 SFV strain, and
- (c) a transgene.
Dependencies are inferred from the claim text.