Silicified immunogenic cells, methods of making, and methods of using
AssigneeUNM Rainforest Innovations
InventorsRita E. Serda, Jimin Guo
Life of this patent
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Abstract
A pharmaceutical composition includes a silicified cell or fraction thereof, a cationic layer disposed on at least a portion of the surface of the silicified cell or fraction thereof, and an immunomodulatory moiety bound to at least a portion of the cationic layer. Alternatively, the pharmaceutical composition includes a silicified cell or fraction thereof, a cationic layer disposed on at least a portion of the surface of the silicified cell or fraction thereof, an anionic layer disposed on at least a portion of the cationic layer, and an immunomodulatory moiety bound to at least a portion of the anionic layer.
Claims15
A pharmaceutical composition comprising:
- a silicified cell, a silicified cell-derived body, or a silicified vesicle, the silicified cell, silicified cell-derived body, or silicified vesicle comprising a silicified surface;
- a cationic layer disposed on at least a portion of the silicified surface;
- and
- an immunomodulatory moiety bound to at least a portion of the cationic layer.
A method for treating a subject having, or at risk of having, a tumor, the method comprising:
- providing a silicified tumor cell comprising:
- a silicified surface;
- a cationic layer disposed on at least a portion of the silicified surface of the silicified tumor cell;
- and
- an immunomodulatory moiety bound to at least a portion of the cationic layer;
- and
- administering the silicified tumor cell to the subject in an amount effective to ameliorate at least one symptom or clinical sign of having the tumor.
Dependencies are inferred from the claim text.