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US 12,196,763 B2Granted
Compositions and methods for predicting post-surgical cardiovascular events
AssigneesThe Trustees of the University of Pennsylvania, American Heart Association, Inc.
InventorsWade T. Rogers, Jana M. Schmierer, Jonni S. Moore, Emile R. Mohler, III
Life of this patent
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Abstract
This disclosure provides for compositions and methods that can be used to predict an individual's risk for experiencing a cardiovascular event following a surgical procedure (e.g., a non-cardiac surgical procedure).
Claims15
A method of classifying risk of having a cardiovascular event after a non-cardiac vascular surgical procedure in an individual, the method comprising
- providing a biological sample from the individual;
- via flow cytometry, determining the number of extracellular vesicles (EVs) in the biological sample expressing a set of biological markers, the set of biological markers comprising at least two of CD31+, CD105+, and CD64+;
- and
- classifying the individual as low risk of having a post-surgical cardiovascular event or as high risk of having a post-surgical cardiovascular event based upon the number of EVs in the biological sample expressing the set of biological markers.
1 more element
A method of detecting the presence of vulnerable plaques in an individual, comprising:
- providing a biological sample from the individual;
- and
- via flow cytometry, determining the number of monocyte-derived extracellular vesicles (MEVs) in the biological sample expressing a set of biological markers, the set of biological markers comprising at least two of CD31+, CD105+, and/or CD64+;
- wherein an increase in the number of MEVs in the biological sample is indicative of plaque vulnerability.
1 more element
Dependencies are inferred from the claim text.