Modified fibroin fibers
AssigneeSpiber Inc.
InventorsYunosuke Abe, Masato Matsuo, Shota Togashi
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Abstract
The present invention provides a modified fibroin fiber having a shrinkage history of being irreversibly shrunk after spinning, the modified fibroin fiber containing modified fibroin, wherein a fiber diameter of a raw material fiber before being irreversibly shrunk exceeds 25 μm.
Claims20
A modified fibroin fiber having a shrinkage history of being irreversibly shrunk after spinning, the modified fibroin fiber comprising modified fibroin, wherein a fiber diameter of a raw material fiber before being irreversibly shrunk is from 55 to 100 μm, wherein the modified fibroin comprises a domain sequence represented by Formula 1:
- [(A)n motif-REP]m or Formula 2:
- [(A)n motif-REP]m-(A)n motif, in which:
- (A)n motif represents an amino acid sequence consisting of 2 to 27 amino acid residues, and a proportion of the number of alanine residues to a total number of amino acid residues in the (A)n motif is 40% or more;
- REP represents an amino acid sequence consisting of 2 to 200 amino acid residues;
- and
- m represents an integer from 2 to 300,
- wherein a plurality of (A), motifs is the same amino acid sequences or different amino acid sequences, wherein a plurality of REP is the same amino acid sequences or different amino acid sequences, and wherein the domain sequence has an amino acid sequence corresponding to deletion of one or a plurality of glutamine residues in REP or substitution of one or a plurality of glutamine residues with another amino acid residue, as compared with the naturally derived fibroin.
A production method of a modified fibroin fiber, comprising a shrinking step of irreversibly shrinking a raw material fiber,
- wherein the raw material fiber contains modified fibroin, and before the shrinking step, the raw material fiber has a fiber diameter from 55 to 100 μm,
- wherein the modified fibroin comprises a domain sequence represented by Formula 1:
- [(A)n motif-REP]m or Formula 2:
- [A]n motif-REP]m-(A)n motif, in which:
- (A)n motif represents an amino acid sequence consisting of 2 to 27 amino acid residues, and a proportion of the number of alanine residues to a total number of amino acid residues in the (A)n motif is 40% or more;
- REP represents an amino acid sequence consisting of 2 to 200 amino acid residues;
- and
- m represents an integer from 2 to 300,
- wherein a plurality of (A)n motifs is the same amino acid sequences or different amino acid sequences, wherein a plurality of REP is the same amino acid sequences or different amino acid sequences, and wherein the domain sequence has an amino acid sequence corresponding to deletion of one or a plurality of glutamine residues in REP or substitution of one or a plurality of glutamine residues with another amino acid residue, as compared with the naturally derived fibroin.
A modified fibroin fiber comprising modified fibroin, wherein the modified fibroin fiber has a fiber diameter from 55 to 100 μm, and a shrinkage rate is 3.3% or less, the shrinkage rate being defined by the following Equation (1):
- Shrinkage rate (%)=(1−(length of modified fibroin fiber when dried from wet state/length of modified fibroin fiber when in wet state))×100,
- wherein the modified fibroin comprises a domain sequence represented by Formula 1:
- [(A) n motif-REP]m or Formula 2:
- [(A)n motif-REP]m-(A)n motif, in which:
- (A)n motif represents an amino acid sequence consisting of 2 to 27 amino acid residues, and a proportion of the number of alanine residues to a total number of amino acid residues in the (A)n motif is 40% or more;
- REP represents an amino acid sequence consisting of 2 to 200 amino acid residues;
- and
- m represents an integer from 2 to 300,
- wherein a plurality of (A)n motifs is the same amino acid sequences or different amino acid sequences, wherein a plurality of REP is the same amino acid sequences or different amino acid sequences, and wherein the domain sequence has an amino acid sequence corresponding to deletion of one or a plurality of glutamine residues in REP or substitution of one or a plurality of glutamine residues with another amino acid residue, as compared with the naturally derived fibroin.
Dependencies are inferred from the claim text.