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US 12,195,768 B2Granted
System and method for modulating stress granule assembly
AssigneeThe Trustees of Princeton University
InventorsCliff Brangwynne, Victoria Drake, David Sanders
Life of this patent
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Abstract
A system and method for modulating stress granule assembly, utilizing a protein construct that has a cell penetrating protein fused to one or more proteins that can bind with an NTF2-like domain of a G3BP protein. By configuring the protein construct with an appropriate number of proteins that being with NTF2-like domains, stress granule assembly can be upregulated or downregulated as needed to treat patients.
Claims13
A protein construct for use in upregulating stress granule formation comprising:
- a cell penetrating protein fused to k binding proteins that can bind to a NTF2-like domain, each binding protein comprises the first 142 amino acids of G3BP1, wherein 1<k≤10.
Dependencies are inferred from the claim text.