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US 12,195,569 B2Granted
Radiopaque polymers
AssigneeBoston Scientific Medical Device Limited
InventorsAndrew Lennard Lewis, Hugh Britton, Yiqing Tang, Jonathan Vince, Koorosh Ashrafi, Damien Guégan
Life of this patent
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Abstract
This invention relates to radiopaque polymers and to their use, particularly in the manufacture of medical devices and in methods of medical treatment, including therapeutic embolization. In particular embodiments the present disclosure relates to a hydrophilic polymer comprising pendent groups which a phenyl ring is substituted with one or more iodine groups and one or more non-iodine groups as described in more detail herein.
Claims19
A hydrophilic polymer comprising pendent groups of the formula I:
- wherein:
- W is independently selected from —OH, —COOH, —SO3H, —OPO3H, —O—(C1-4 alkyl), —O—(C1-4 alkyl)OH, —O—(C1-4 alkyl)R2, —O—(C2H5O)qR1, —(C═O)—O—C1-4 alkyl and —O—(C═O)C1-4 alkyl, where —OH, —COOH, —O—PO3H and —SO3H may be in the form of a pharmaceutically acceptable salt;
- or a group —BZ;
- B is a bond, or a straight branched alkanediyl, oxyalkylene, alkylene oxaalkylene, or alkylene group, optionally containing one or more fluorine substituents;
- and
- Z is an ammonium, phosphonium, or sulphonium phosphate or phosphonate ester zwitterionic group;
- X is either a bond or a linking group having 1 to 8 carbons and optionally 1 to 4 heteroatoms selected from O, N and S;
- G is a coupling group through which the group of the formula I is coupled to the polymer and is selected from 1,3-dioxolane and 1,3 dioxane;
- R1 is H or C1-4 alkyl;
- R2 is —COOH, —SO3H, or —OPO3H2
- q is an integer from 1 to 4;
- n is an integer from 1 to 4;
- p is an integer from 1 to 3;
- and
- n+p is from 2 to 5.
12 more elements
Dependencies are inferred from the claim text.