Anti-inflammatory compounds and methods of use
AssigneeUniversity of Oregon
InventorsKaren Guillemin, Annah Rolig, Emily Sweeney
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Abstract
Methods of treating or inhibiting inflammation in a subject include administering an anti-inflammatory protein to the subject. In some embodiments, the protein has at least 80% sequence identity to the amino acid sequence set forth as SEQ ID NO: 1, SEQ ID NO: 11, or fragments thereof. Isolated polypeptides, nucleic acids, and recombinant vectors including a nucleic acid encoding the anti-inflammatory protein (such as a nucleic acid encoding a protein with at least 80% sequence identity to SEQ ID NO: 1, SEQ ID NO: 11, or fragments thereof) operably linked to a heterologous promoter are also disclosed.
Claims6
A method of treating inflammatory bowel disease, Hirschsprung's associated enterocolitis, irritable bowel syndrome, or necrotizing enterocolitis in a subject, comprising administering to the subject a polypeptide comprising:
- an amino acid sequence comprising the amino acid sequence of SEQ ID NO:
- 11;
- or
- an amino acid sequence comprising amino acids 1-188 of SEQ ID NO:
- 11, amino acids 21-188 of SEQ ID NO:
- 11, or amino acids 189-330 of SEQ ID NO:
- 11.
Dependencies are inferred from the claim text.