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US 12,195,500 B2Granted
Antibodies against disease causing agents of canines and felines and uses thereof
AssigneeNovobind Livestock Therapeutics Inc.
InventorsHamlet Abnousi, Slade Andrew Loutet, Filip Van Petegem, Tsz Ying Sylvia Cheung
Life of this patent
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Abstract
Described herein are methods and antibodies useful for reducing, eliminating, or preventing infection with a viral population in an animal. Also described herein are antigens useful for targeting by heavy chain antibodies and VHH fragments for reducing a viral population in an animal.
Claims6
A polypeptide comprising at least one variable region fragment of a heavy chain antibody (VHH), wherein the at least one VHH specifically binds a parvovirus, and wherein the polypeptide:
- a) prevents red blood cell hemagglutination by canine parvovirus type 2C capsid at a concentration lower than 100 nM, and the at least one VHH comprises an amino acid sequence at least 95% identical to an amino acid sequence of any one of SEQ ID Nos:
- 1, 4, 6, 8, 10, 13 or 17;
- b) prevents red blood cell hemagglutination by canine parvovirus type 2C capsid at a concentration lower than 1 μM, and the at least one VHH comprises an amino acid sequence at least 95% identical to an amino acid sequence of any one of SEQ ID Nos 1, 4, 6, 7, 8, 10, 13, 17 or 77;
- or
- c) reduces invasion of Madin-Darby canine kidney (MDCK} cells by canine parvovirus by >50% at 5 μM, and the at least one VHH comprises an amino acid sequence at least 95% identical to an amino acid sequence of any one of SEQ ID Nos:
- 1, 4, 10, 15 or 17.
3 more elements
Dependencies are inferred from the claim text.