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US 12,195,451 B2Granted
Compositions and methods for viral sensitization
AssigneeOttawa Hospital Research Institute and University of Ottawa
InventorsJean-Simon Diallo, Christopher Noyce Boddy, Mark Dornan, Ramya Krishnan, Rozanne Arulanandam, Fabrice Le Boeuf, Jeffrey Smith, Andrew Macklin
Life of this patent
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Abstract
Provided are compounds of Formula III that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.
Claims7
A compound of formula (III):
- wherein:
- X5 is linear or branched C1-C12alkyl, C2-C12 alkenyl, C2-C12 alkynyl, or C3-C5cycloalkyl, wherein the C1-C12alkyl, C2-C12 alkenyl, C2-C12 alkynyl, and C3-C5cycloalkyl groups are unsubstituted or substituted with one or more of —SH, —NRxRy, —NRxSO2Rz, phenyl, naphthyl, 5- to 6-membered heteroaryl, cycloalkyl or heterocycloalkyl, where each phenyl, naphthyl, heteroaryl, cycloalkyl and heterocycloalkyl are unsubstituted or substituted with one or more of —OH, —C1-C6alkyl, —C1-C6alkoxy, halogen, —SO2C1-C6alkyl, —CF3, —NO2, phenyl, benzyl, or —C1-C6alkyleneC(O)ORx;
- Rx is H or C1-C6alkyl;
- Ry is H or C1-C6alkyl;
- Rz is phenyl, naphthyl, dimethylamino-naphthyl or heteroaryl;
- provided that when X5 is C1alkyl substituted with phenyl, the phenyl is substituted, or a pharmaceutically acceptable salt, or stereochemically isomeric form thereof.
3 more elements
Dependencies are inferred from the claim text.