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US 12,195,424 B2Granted
Antibiotic compounds
AssigneesThe General Hospital Corporation, Rhode Island Hospital, A Lifespan-Partner, Temple University of the Commonwealth System of Higher Education
InventorsFrederick M. Ausubel, Wooseong Kim, Eleftherios Mylonakis, William M. Wuest
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Abstract
The present application provides compounds and methods of treating bacterial infection, including bacterial infection caused by P. acnes.
Claims19
A compound of Formula (III)
- or a pharmaceutically acceptable salt thereof, wherein:
- L1 is C1-3 alkylene, or L1 is absent;
- R2a, R3a, and R4a are each independently selected from H and OH;
- R2b, R4b, R5b, and R7b are each independently selected from H, OH, HO—C1-3 alkylene, and —C(═O)OH;
- and
- at least one of R3b and R6b is OH and the other of R3b and R6b is selected from H, OH, HO—C1-3 alkylene, and —C(═O)OH.
3 more elements
A method of treating a bacterial infection in a human subject in need thereof, the method comprising administering to the human subject a therapeutically effective amount of a compound of Formula (III):
- or a pharmaceutically acceptable salt thereof, wherein:
- L1 is C1-3 alkylene, or L1 is absent;
- R2a, R3a, and R4a are each independently selected from H and OH;
- and
- R2b, R3b, R4b, R5b, R6b, and R7b are each independently selected from H, OH, HO—C1-3 alkylene, and —C(O)OH.
2 more elements
Dependencies are inferred from the claim text.