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US 12,194,265 B2Granted
Controlled outgassing of hyperbarically loaded materials for the delivery of oxygen and other therapeutic gases in biomedical applications
AssigneeThe Johns Hopkins University
InventorsColin Cook, Warren Grayson
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Abstract
Devices and methods for delivering oxygen and other therapeutic gases to a target, such as a tissue, a tissue-engineered construct, and a wound, in a controlled and sustained manner are disclosed.
Claims18
A method for delivering one or more gases to a target in a controlled and sustained manner, the method comprising:
- (a) providing one or more microtanks having a hollow core-shell morphology having an exterior comprising a polymeric material selected from the group consisting of polyethylene terephthalate (PET), polycaprolactone (PCL), poly (lactic-co-glycolic acid) (PLGA), poly (lactic acid) (PLA), and poly (glycolic acid) (PGA), and an interior comprising a material selected from the group consisting of polyvinyl alcohol (PVOH), a phenolic resin, and porous silica. wherein the interior of the core-shell comprises a void having a shape of a microbubble, a microballoon, a microsphere, or a microtube, wherein the void comprises one or more gases at a hyperbaric pressure and has a spherical shape having a diameter ranging from about 1 nanometer to about 1000 micrometers;
- (b) loading the one or more microtanks with one or more gases;
- and
- (c) releasing the one or more gases via diffusion to the target in a controlled and sustained manner.
1 more element
Dependencies are inferred from the claim text.