High anticoagulation ECMO and extracorporeal circulation consumable

A high anticoagulation extracorporeal membrane oxygenation (ECMO) device and extracorporeal circulation consumables, comprising the following preparation methods:

• S1, aminating a surface of the ECMO device and extracorporeal circulation consumables:
• adding raw materials containing amino functional groups into an organic solvent to obtain a first mixture solution, stirring and mixing the first mixture solution, pouring the first mixture solution into the ECMO device and extracorporeal circulation consumables, refluxing at a temperature ranging from 20° C. to 80° C. for 2 to 10 hours, to graft the raw materials containing amino functional groups onto an inner wall of the ECMO device and extracorporeal circulation consumables contacting with blood, so that the inner wall are loaded with amino functional groups, and washing to obtain amino-modified ECMO device and extracorporeal circulation consumables;
• S2, activating heparin groups by direct coupling method:
• dissolving heparin sodium in 2-(N-morpholino)ethanesulfonic acid (MES) buffer to obtain a heparin solution, adding 1-Ethyl-3-(3-dimethylaminopropyl)carbodimide(EDC) and N-Hydroxysuccinimide (NHS) to the heparin solution to obtain a second mixture solution, and stirring the second mixture solution in an ice-water bath for 1 to 5 hours to activate active groups of heparin and generate an activated heparin solution containing active carboxyl groups;
• S3, heparinizing the amino-modified ECMO device and extracorporeal circulation consumables:
• adding the activated heparin solution into the amino-modified ECMO device and extracorporeal circulation consumables, refluxing for 1 to 20 hours and discharging the activated heparin solution, washing the amino-modified ECMO device and extracorporeal circulation consumables with a mixed solution of ethanol and distilled water to obtain a heparinized ECMO device and extracorporeal circulation consumables;
• S4, modifying the heparinized ECMO device and extracorporeal circulation consumables with enhances:
• modifying a surface of the heparinized ECMO device and extracorporeal circulation consumables with albumin, functionalized polyethylene glycol (PEG) which can react with amino groups, and phosphate to block sites on the heparinized ECMO device and extracorporeal circulation consumables not modified by heparinization process, to shield adsorption of platelets and protein in blood on the inner wall.