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US 12,194,111 B2Granted
Alpha emitter compositions and methods
AssigneeNant Holdings IP, LLC
InventorPatrick Soon-Shiong
Life of this patent
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Abstract
Compositions, methods, and uses of an alpha emitter are provided in which the alpha emitter is coupled to carrier protein via a cleavable coupling moiety. The coupling moiety is preferably cleavable in an acidic tumor microenvironment, and as such will enrich the alpha emitter upon cleavage within the tumor microenvironment.
Claims7
A synthetic alpha-emitter-conjugated compound, consisting essentially of:
- an alpha-emitter coupled to a coupling moiety that comprises a linker portion and a chelator portion;
- wherein the linker portion has a protein binding group and wherein the chelator portion chelates the alpha-emitter;
- wherein the coupling moiety comprises an acid labile hydrazone moiety that is cleavable in an acidic tumor microenvironment;
- wherein the coupling moiety is represented by the following Formula 1:
- and
- optionally a protein coupled to the protein binding group.
3 more elements
A method of delivering an alpha-emitter to a tumor, comprising:
- administering an alpha-emitter coupled to a coupling moiety that comprises a linker portion and a chelator portion;
- wherein the linker portion has a protein binding group and wherein the chelator portion chelates the alpha-emitter;
- wherein the coupling moiety comprises an acid labile hydrazone moiety that is cleavable in an acidic tumor microenvironment;
- and
- wherein the coupling moiety is represented by the following Formula 1:
2 more elements
Dependencies are inferred from the claim text.