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US 12,194,033 B2Granted
Glycine receptor modulators and methods of use
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsYan Xu, Pei Tang, Marta Megan Wells
Life of this patent
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Abstract
Compounds and methods for modulating the activity of receptors are disclosed. Some of the compounds modulate the activity of glycine receptors. Certain embodiments of the compounds are useful for treatment of pain, treatment of opioid addiction, and/or reduction of side effects attributable to opioid use.
Claims17
A method for treating opioid addiction and/or reducing side effects attributable to opioid use in a subject, comprising:
- administering to the subject an effective amount of a compound having a structure according to formula I, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof:
- where R1, R2, R3, and R4 independently are hydrogen, halo, or hydroxy;
- R5 is hydrogen, halo, C1-C10 alkyl, or hydroxy;
- R6 and R7 independently are hydrogen, halo, hydroxy, C1-C10 alkyl, or C1-C10 alkyl carboxamide, or R6 and R7 together with the nitrogen to which they are bound form a heterocycloaliphatic or heteroaryl group;
- and
- n is 0, 1, 2, or 3.
3 more elements
Dependencies are inferred from the claim text.