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US 12,194,008 B2Granted
Nasal formulations of metoclopramide
AssigneeEvoke Pharma, Inc.
InventorsMatthew J. D'Onofrio, David A. Gonyer, Shirish A. Shah, Stuart J. Madden
Life of this patent
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Abstract
Nasal formulations of metoclopramide, which remain stable and/or colorless upon storage over a period of time, are provided. Also provided are methods of treating disorders treatable with metoclopramide, comprising administering the nasal solutions to patients in need thereof.
Claims17
A method of treating gastroparesis in a patient, comprising intranasally administering to the patient an amount of a metoclopramide composition effective to deliver a daily dose of about 30 mg to about 60 mg of metoclopramide, or a pharmaceutically-acceptable salt thereof,
- wherein the metoclopramide composition comprises citrate in a concentration of at least about 10 millimolar, and
- wherein the intranasally administering is effective to treat gastroparesis.
Dependencies are inferred from the claim text.