Back to results
US 12,193,996 B2Granted
Monocyte compositions and methods for the treatment of infectious disease
AssigneesThe General Hospital Corporation, President and Fellows of Harvard College
InventorsCatherine Rhee, David T. Scadden
Life of this patent
Estimating the term…
Abstract
Described herein are compositions comprising subsets of monocyte having distinct functional properties and methods for using the same to treat infectious disease.
Claims6
A method of treating a microbial infection in a tissue of a subject, the method comprising administering to the subject a composition comprising isolated monocyte cells that express Cd49f, Cd54, and Cd11b;
- and express an increased level of Bcl6, Tlr4, Tlr9, Notch2 and Illr1, and secrete an increased level of cytokines IL6 and TNF alpha compared to classical and non-classical monocytes, thereby treating the microbial infection in the tissue of the subject.
Dependencies are inferred from the claim text.