# US 12,193,137 B2 · Apparatus and methods for treatment using non-thermal plasma

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- Number: US 12,193,137 B2
- Document ID: US12193137B2
- Status: Granted
- Kind: B2
- Application number: 18/629,710
- Filed: 2024-04-08
- Published: 2024-08-15
- Granted: 2025-01-07
- Earliest claimed: 2015-09-30
- Assignees: Chiscan Holdings Pte. Ltd.
- Applicants: ChiScan Holdings Pte. Ltd
- Inventors: Bradley N. Eckert; Huan Truong; Bryon K. Eckert
- Web page: https://patentgrep.com/patent/US12193137B2

## CPC

- A61B 90/80: Implements for cleaning or washing the skin of surgeons or patients
- H05H 1/2406: {using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes}
- A61B 18/042: {using additional gas becoming plasma}
- A61L 2/02: using physical processes
- A61L 2/14: Plasma, i.e. ionised gases
- A61B 2018/00583: {Coblation, i.e. ablation using a cold plasma}
- A61B 2018/00732: {Frequency}
- A61L 2103/00: Materials or objects being the target of disinfection or sterilisation
- A61L 2103/05: Living organisms or biological materials
- A61L 2202/11: Apparatus for generating biocidal substances, e.g. vaporisers, UV lamps
- A61L 2202/14: Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
- H05H 1/47: {using corona discharges}
- H05H 2240/20: Non-thermal plasma
- H05H 2245/34: Skin treatments, e.g. disinfection or wound treatment
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- H05H: PLASMA TECHNIQUE (apparatus or processes specially adapted for producing X-rays H05G2/00); PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

An array of non-thermal plasma emitters is controlled to emit plasma based on application of an electric current at desired frequencies and a controlled power level. A power supply for an array controller includes a transformer that operates at the resonant frequency of the combined capacitance of the array and the cable connecting the array to the power supply. The power into the array is monitored by the controller and can be adjusted by the user. The controller monitors reflected power characteristics, such as harmonics of the alternating current, to determine initiation voltage of the plasma and/or resonant frequency plasma emitters. The array of non-thermal plasma emitters may be used in therapeutic, diagnostic, and/or medical sanitization applications, including where a non-thermal plasma treatment regimen is prescribed according to a prescription setting.

## Claims

### Claim 1

A device for applying a prescribed treatment, the device comprising:
a substrate;
a plurality of plasma emitters on the substrate, each plasma emitter in the plurality of plasma emitters configured to electrically ionize air surrounding the plasma emitter to produce a non-thermal plasma;
a memory device on the substrate, the memory device configured to store a prescription setting identifying an operational attribute of the device, wherein the prescription setting is associated with:
a treatment duration,
a modulation frequency, and
a treatment plan indicating a number of treatments per day; and
a set of terminals on the substrate electrically connected to the plurality of plasma emitters, the set of terminals receiving an electrical connection to a controller configured to:
read the prescription setting from the memory device, and
responsive to reading the prescription setting, control application of an alternating current at the modulation frequency to at least a first plasma emitter of the plurality of plasma emitters to cause the first plasma emitter to produce a first non-thermal plasma.

### Claim 2 (depends on 1)

The device of claim 1, further comprising a power supply in electronic communication with the controller and electrically connectable to the set of terminals by a cable to apply the alternating current, the controller being further configured to:
measure a reflected power signal of the cable; and
based on the reflected power signal, modulate the power supply to set a constant plasma power level.

### Claim 3 (depends on 2)

The device of claim 2, wherein a first frequency of the reflected power signal is a second or higher-order harmonic frequency of a second frequency of the alternating current.

### Claim 4 (depends on 1)

The device of claim 1, wherein the controller is further configured to, responsive to reading the prescription setting, control application of the alternating current for a time period that does not exceed the treatment duration.

### Claim 5 (depends on 1)

The device of claim 1, wherein the memory device is configured to receive, from the controller, a parameter of an operation of the controller and to store the parameter in the memory device.

### Claim 6 (depends on 1)

The device of claim 1, wherein the memory device stores an identification code that, when read by the controller, indicates to the controller that the array is authorized for use.

### Claim 7

A device for applying a prescribed treatment, the device comprising:
an array including:
a substrate, and
a plasma emitter on the substrate;
a cable configured to electrically connect a power supply to the array; and
a memory device associated with the array, the memory device storing a prescription setting associated with:
a treatment duration, and
a frequency setting; and
a controller comprising a port for connecting to the array via the cable, the controller configured to:
receive the prescription setting from the memory device, and
control a power supply in accordance with the prescription setting to modulate an alternating current transmitted to the plasma emitter in accordance with the prescription setting.

### Claim 8 (depends on 7)

The device of claim 7, wherein the controller is configured to determine a reflected power signal of the cable.

### Claim 9 (depends on 8)

The device of claim 8, wherein a first frequency of the reflected power signal is a second or higher-order harmonic frequency of a second frequency of the alternating current.

### Claim 10 (depends on 7)

The device of claim 7, wherein the controller is configured to control the power supply to generate plasma at the plasma emitter, wherein a frequency of the plasma is the same as the frequency setting.

### Claim 11 (depends on 7)

The device of claim 7, wherein the controller is further configured to control the power supply in accordance with the prescription setting to generate the alternating current for a time period that does not exceed the treatment duration.

### Claim 12 (depends on 7)

The device of claim 7, wherein the memory device is disposed on the substrate of the array.

### Claim 13 (depends on 12)

The device of claim 12, wherein the controller is configured to store a parameter of an operation of the controller in the memory device of the array.

### Claim 14 (depends on 12)

The device of claim 12, wherein the memory device stores an identification code and the controller is configured to:
receive the identification code from the memory device; and
determine that the identification code indicates that the cable is authorized for use.

### Claim 15

A method for applying a prescribed treatment, the device comprising:
receiving, by a controller of a plasma treatment device, a prescription setting from a memory device of an array, the array including a plurality of plasma emitters on a substrate, wherein the prescription setting is associated with:
a treatment duration, and
a modulation frequency; and
controlling, by the controller, a power supply in accordance with the prescription setting to modulate, at the modulation frequency, an alternating current transmitted to at least a first plasma emitter of the plurality of plasma emitters to cause the first plasma emitter to produce a first non-thermal plasma.

### Claim 16 (depends on 15)

The method of claim 15, wherein the power supply is electrically connected to the array by a cable, the method further comprising measuring, by the controller, a reflected power signal of the cable.

### Claim 17 (depends on 15)

The method of claim 15, further comprising controlling, by the controller, the power supply to generate the alternating current at the power level.

### Claim 18 (depends on 15)

The method of claim 15, further comprising controlling, by the controller, the power supply in accordance with the prescription setting to generate the alternating current for a time period that does not exceed the treatment duration.

### Claim 19 (depends on 15)

The method of claim 15, wherein the memory device stores an identification code, the method further comprising:
receiving, by the controller, the identification code from the memory device; and
determining, by the controller, that the identification code indicates that the array is authorized for use.