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US 12,188,945 B2Granted
Food-allergen specific antibody compositions
AssigneeVanderbilt University
InventorScott A. Smith
Life of this patent
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Abstract
The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom. Such engineered antibodies can be used to blunt pathologic IgE responses in subjects, such as in the treatment or prevention of allergies.
Claims9
A pharmaceutical composition comprising:
- a therapeutically effective amount of an antibody or a fragment thereof, wherein the antibody or the fragment thereof binds a food allergen, wherein the food allergen is a peanut allergen and the antibody or the fragment thereof comprises heavy chain CDR1 SEQ ID NO:
- 105, heavy chain CDR2 SEQ ID NO:
- 106, heavy chain CDR3 SEQ ID NO:
- 107, light chain CDR1 SEQ ID NO:
- 183, light chain CDR2 of sequence KAS and light chain CDR3 SEQ ID NO:
- 185;
- and
- a pharmaceutically acceptable carrier.
5 more elements
Dependencies are inferred from the claim text.