Peptides and conjugates
AssigneeThe University of Liverpool
InventorAnthony Hollander
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Abstract
Provided are peptides, and conjugates comprising targeting peptides and payloads. The peptides comprise a plurality of modules corresponding to at least one of module 1, module 2, or module 3 of the collagen binding domain of a gelatinase, or a gelatin-binding fragment or variant thereof. The gelatinase may be MMP-2. The conjugates may be therapeutic or non-therapeutic. Medical uses of the peptides or therapeutic conjugates, and pharmaceutical compositions comprising these, are also provided, as are nucleic acids encoding the peptides.
Claims20
A peptide comprising a plurality of modules corresponding to module 1 of the collagen binding domain of MMP-2, a plurality of modules corresponding to module 2 of the collagen binding domain of MMP-2, or a plurality of modules corresponding to module 3 of the collagen binding domain of MMP-2, wherein module 1 comprises the amino acid sequence set out in SEQ ID NO:
- 6 or a sequence with at least 90% sequence identity thereto, wherein module 2 comprises the amino acid sequence set out in SEQ ID NO:
- 11 or a sequence with at least 90% sequence identity thereto, and wherein module 3 comprises the amino acid sequence set out in SEQ ID NO:
- 17 or a sequence with at least 90% sequence identity thereto.
A conjugate comprising a targeting peptide and a payload, wherein the targeting peptide comprises a plurality of module 1 of the collagen binding domain of MMP-2, a plurality of module 2 of the collagen binding domain of MMP-2, or a plurality of module 3 of the collagen binding domain of a MMP-2, wherein module 1 comprises the amino acid sequence set out in SEQ ID NO:
- 6 or a sequence with at least 90% sequence identity thereto, wherein module 2 comprises the amino acid sequence set out in SEQ ID NO:
- 11 or a sequence with at least 90% sequence identity thereto, and wherein module 3 comprises the amino acid sequence set out in SEQ ID NO:
- 17 or a sequence with at least 90% sequence identity thereto.
Dependencies are inferred from the claim text.